5ZHP

M3 muscarinic acetylcholine receptor in complex with a selective antagonist

Summary for 5ZHP

• Entry DOI: 10.2210/pdb5zhp/pdb
• Related PRD ID: PRD_900001
• Descriptor: Muscarinic acetylcholine receptor M3,Endolysin,Endolysin,Muscarinic acetylcholine receptor M3, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, TETRAETHYLENE GLYCOL, ... (6 entities in total)
• Functional Keywords: g protein coupled receptor, membrane protein
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 2
• Total formula weight: 97646.19

Authors

Liu, H.,Hofmann, J.,Fish, I.,Schaake, B.,Eitel, K.,Bartuschat, A.,Kaindl, J.,Rampp, H.,Banerjee, A.,Hubner, H.,Clark, M.J.,Vincent, S.G.,Fisher, J.,Heinrich, M.,Hirata, K.,Liu, X.,Sunahara, R.K.,Shoichet, B.K.,Kobilka, B.K.,Gmeiner, P. (deposition date: 2018-03-13, release date: 2018-11-28, Last modification date: 2023-11-22)

• Primary citation: Liu, H.,Hofmann, J.,Fish, I.,Schaake, B.,Eitel, K.,Bartuschat, A.,Kaindl, J.,Rampp, H.,Banerjee, A.,Hubner, H.,Clark, M.J.,Vincent, S.G.,Fisher, J.T.,Heinrich, M.R.,Hirata, K.,Liu, X.,Sunahara, R.K.,Shoichet, B.K.,Kobilka, B.K.,Gmeiner, P.; Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists; Proc. Natl. Acad. Sci. U.S.A., 115:12046-12050, 2018; PubMed: 30404914; DOI: 10.1073/pnas.1813988115

Experimental method

X-RAY DIFFRACTION (3.1 Å)