Author results

1Y6Q
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CYRSTAL STRUCTURE OF MTA/ADOHCY NUCLEOSIDASE COMPLEXED WITH MT-DADME-IMMA
分子名称:MTA/SAH nucleosidase, CHLORIDE ION, (3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL
著者Lee, J.E., Singh, V., Evans, G.B., Tyler, P.C., Furneaux, R.H., Cornell, K.A., Riscoe, M.K., Schramm, V.L., Howell, P.L.
登録日2004-12-06
公開日2005-03-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
J.Biol.Chem., 280, 2005
1Y6R
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CRYSTAL STRUCTURE OF MTA/ADOHCY NUCLEOSIDASE COMPLEXED WITH MT-IMMA.
分子名称:MTA/SAH nucleosidase, (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL
著者Lee, J.E., Singh, V., Evans, G.B., Tyler, P.C., Furneaux, R.H., Cornell, K.A., Riscoe, M.K., Schramm, V.L., Howell, P.L.
登録日2004-12-06
公開日2005-03-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
J.Biol.Chem., 280, 2005
1B8N
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PURINE NUCLEOSIDE PHOSPHORYLASE
分子名称:PURINE NUCLEOSIDE PHOSPHORYLASE, MAGNESIUM ION, PHOSPHATE ION, ...
著者Fedorov, A.A., Kicska, G.A., Fedorov, E.V., Strokopytov, B.V., Tyler, P.C., Furneaux, R.H., Schramm, V.L., Almo, S.C.
登録日1999-02-02
公開日1999-02-08
最終更新日2019-10-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase
Biochemistry, 41, 2002
1B8O
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PURINE NUCLEOSIDE PHOSPHORYLASE
分子名称:PURINE NUCLEOSIDE PHOSPHORYLASE, MAGNESIUM ION, PHOSPHATE ION, ...
著者Fedorov, A.A., Kicska, G.A., Fedorov, E.V., Shi, W., Tyler, P.C., Furneaux, R.H., Schramm, V.L., Almo, S.C.
登録日1999-02-02
公開日1999-02-08
最終更新日2019-10-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis.
Biochemistry, 40, 2001
1BZY
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HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR
分子名称:HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, PHOSPHORIC ACID MONO-[5-(2-AMINO-4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXY-PYRROLIDIN-2-YLMETHYL] ESTER, ...
著者Shi, W., Li, C., Tyler, P.C., Furneaux, R.H., Grubmeyer, C., Schramm, V.L., Almo, S.C.
登録日1998-11-05
公開日1999-06-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor.
Nat.Struct.Biol., 6, 1999
1CJB
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MALARIAL PURINE PHOSPHORIBOSYLTRANSFERASE
分子名称:PROTEIN (HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE), MAGNESIUM ION, (1S)-1(9-DEAZAHYPOXANTHIN-9YL)1,4-DIDEOXY-1,4-IMINO-D-RIBITOL-5-PHOSPHATE, ...
著者Shi, W., Li, C.M., Tyler, P.C., Furneaux, R.H., Cahill, S.M., Girvin, M.E., Grubmeyer, C., Schramm, V.L., Almo, S.C.
登録日1999-04-08
公開日1999-08-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor.
Biochemistry, 38, 1999
1DQN
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CRYSTAL STRUCTURE OF GIARDIA GUANINE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH A TRANSITION STATE ANALOGUE
分子名称:GUANINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, PHOSPHORIC ACID MONO-[5-(2-AMINO-4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXY-PYRROLIDIN-2-YLMETHYL] ESTER, ...
著者Shi, W., Munagala, N.R., Wang, C.C., Li, C.M., Tyler, P.C., Furneaux, R.H., Grubmeyer, C., Schramm, V.L., Almo, S.C.
登録日2000-01-04
公開日2000-07-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,).
Biochemistry, 39, 2000
1DQP
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CRYSTAL STRUCTURE OF GIARDIA GUANINE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH IMMUCILLING
分子名称:GUANINE PHOSPHORIBOSYLTRANSFERASE, 1,4-DIDEOXY-1,4-IMINO-1-(S)-(9-DEAZAGUANIN-9-YL)-D-RIBITOL, ISOPROPYL ALCOHOL
著者Shi, W., Munagala, N.R., Wang, C.C., Li, C.M., Tyler, P.C., Furneaux, R.H., Grubmeyer, C., Schramm, V.L., Almo, S.C.
登録日2000-01-04
公開日2000-07-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,).
Biochemistry, 39, 2000
1G2O
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CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH A TRANSITION-STATE INHIBITOR
分子名称:PURINE NUCLEOSIDE PHOSPHORYLASE, PHOSPHATE ION, 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL
著者Shi, W., Basso, L.A., Tyler, P.C., Furneaux, R.H., Blanchard, J.S., Almo, S.C., Schramm, V.L.
登録日2000-10-20
公開日2001-08-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces.
Biochemistry, 40, 2001
1I80
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CRYSTAL STRUCTURE OF M. TUBERCULOSIS PNP IN COMPLEX WITH IMINORIBITOL, 9-DEAZAHYPOXANTHINE AND PHOSPHATE ION
分子名称:PURINE NUCLEOSIDE PHOSPHORYLASE, PHOSPHATE ION, 9-DEAZAHYPOXANTHINE, ...
著者Shi, W., Basso, L.A., Tyler, P.C., Furneaux, R.H., Blanchard, J.S., Almo, S.C., Schramm, V.L.
登録日2001-03-12
公開日2001-08-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces.
Biochemistry, 40, 2001
1K27
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CRYSTAL STRUCTURE OF 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE IN COMPLEX WITH A TRANSITION STATE ANALOGUE
分子名称:5'-Deoxy-5'-Methylthioadenosine Phosphorylase, PHOSPHATE ION, (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL
著者Shi, W., Singh, V., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.
登録日2001-09-26
公開日2003-09-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A
Biochemistry, 43, 2004
1N3I
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS PNP WITH TRANSITION STATE ANALOG DADME-IMMH
分子名称:Purine Nucleoside Phosphorylase, PHOSPHATE ION, 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
著者Lewandowicz, A., Shi, W., Evans, G.B., Tyler, P.C., Furneaux, R.H., Basso, L.A., Santos, D.S., Almo, S.C., Schramm, V.L.
登録日2002-10-28
公開日2003-09-30
最終更新日2018-12-19
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Over-The-Barrier Transition State Analogues Provide New Chemistries for Inhibitor Design: The Case of Purine Nucleoside Phosphorylase
BIOCHEMISTRY, 42, 2003
1NW4
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM PURINE NUCLEOSIDE PHOSPHORYLASE IN COMPLEX WITH IMMH AND SULFATE
分子名称:uridine phosphorylase, putative, SULFATE ION, ...
著者Shi, W., Ting, L.M., Kicska, G.A., Lewandowicz, A., Tyler, P.C., Evans, G.B., Furneaux, R.H., Kim, K., Almo, S.C., Schramm, V.L.
登録日2003-02-05
公開日2004-03-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Plasmodium falciparum Purine Nucleoside Phosphorylase: CRYSTAL STRUCTURES, IMMUCILLIN INHIBITORS, AND DUAL CATALYTIC FUNCTION.
J.Biol.Chem., 279, 2004
1Q1G
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CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM PNP WITH 5'-METHYLTHIO-IMMUCILLIN-H
分子名称:Uridine phosphorylase putative, SULFATE ION, 3,4-DIHYDROXY-2-[(METHYLSULFANYL)METHYL]-5-(4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)PYRROLIDINIUM, ...
著者Shi, W., Ting, L.M., Kicska, G.A., Lewandowicz, A., Tyler, P.C., Evans, G.B., Furneaux, R.H., Kim, K., Almo, S.C., Schramm, V.L.
登録日2003-07-19
公開日2004-03-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Plasmodium falciparum Purine Nucleoside Phosphorylase: CRYSTAL STRUCTURES, IMMUCILLIN INHIBITORS, AND DUAL CATALYTIC FUNCTION.
J.Biol.Chem., 279, 2004
1RR6
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STRUCTURE OF HUMAN PURINE NUCLEOSIDE PHOSPHORYLASE IN COMPLEX WITH IMMUCILLIN-H AND PHOSPHATE
分子名称:Purine nucleoside phosphorylase, PHOSPHATE ION, 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL
著者Shi, W., Lewandowicz, A., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.
登録日2003-12-08
公開日2005-02-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function.
J.Biol.Chem., 279, 2004
1RSZ
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STRUCTURE OF HUMAN PURINE NUCLEOSIDE PHOSPHORYLASE IN COMPLEX WITH DADME-IMMUCILLIN-H AND SULFATE
分子名称:Purine nucleoside phosphorylase, SULFATE ION, 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
著者Shi, W., Lewandowicz, A., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.
登録日2003-12-10
公開日2005-02-22
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural comparison of human and malarial purine nucleoside phosphorylases
To be Published
1RT9
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STRUCTURE OF HUMAN PURINE NUCLEOSIDE PHOSPHORYLASE IN COMPLEX WITH IMMUCILLIN-H AND SULFATE
分子名称:Purine nucleoside phosphorylase, SULFATE ION, 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL
著者Shi, W., Lewandowicz, A., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.
登録日2003-12-10
公開日2005-02-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural comparison of human and malarial purine nucleoside phosphorylases
To be Published
1ZOS
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STRUCTURE OF 5'-METHYLTHIONADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE FROM S. PNEUMONIAE WITH A TRANSITION-STATE INHIBITOR MT-IMMA
分子名称:5'-methylthioadenosine / S-adenosylhomocysteine nucleosidase, (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL
著者Shi, W., Singh, V., Zhen, R., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.
登録日2005-05-13
公開日2006-04-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae.
Biochemistry, 45, 2006
3EEI
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CRYSTAL STRUCTURE OF 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE FROM NEISSERIA MENINGITIDIS IN COMPLEX WITH METHYLTHIO-IMMUCILLIN-A
分子名称:5-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase, (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL
著者Ho, M., Rinaldo-matthis, A., Brown, R.L., Norris, G.E., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.
登録日2008-09-04
公開日2009-09-08
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from neisseria meningitidis in complex with methylthio-immucillin-A
To be Published
2I4T
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CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE FROM TRICHOMONAS VAGINALIS WITH IMM-A
分子名称:Trichomonas vaginalis purine nucleoside phosphorylase, PHOSPHATE ION, 3,4-PYRROLIDINEDIOL,2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)-2S,3S,4R,5R
著者Rinaldo-Matthis, A., Schramm, V.L., Almo, S.C.
登録日2006-08-22
公開日2007-06-05
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues.
Biochemistry, 46, 2007
2ISC
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CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE FROM TRICHOMONAS VAGINALIS WITH DADME-IMM-A
分子名称:purine nucleoside phosphorylase, PHOSPHATE ION, (3R,4R)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-(HYDROXYMETHYL)PYRROLIDIN-3-OL
著者Rinaldo-Matthis, A., Almo, S.C., Schramm, V.L.
登録日2006-10-17
公開日2007-06-05
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues
Biochemistry, 46, 2007
2Q7O
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STRUCTURE OF HUMAN PURINE NUCLEOSIDE PHOSPHORYLASE IN COMPLEX WITH L-IMMUCILLIN-H
分子名称:Purine nucleoside phosphorylase, PHOSPHATE ION, 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL
著者Rinaldo-Matthis, A., Almo, S.C., Schramm, V.L.
登録日2007-06-07
公開日2008-01-15
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase.
J.Am.Chem.Soc., 130, 2008
3BGS
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STRUCTURE OF HUMAN PURINE NUCLEOSIDE PHOSPHORYLASE WITH L-DADME-IMMH AND PHOSPHATE
分子名称:purine nucleoside phosphorylase, PHOSPHATE ION, 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
著者Murkin, A.S., Ramagopal, U.A., Almo, S.C., Schramm, V.L.
登録日2007-11-27
公開日2008-01-08
最終更新日2018-12-12
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase
J.Am.Chem.Soc., 130, 2008
4WKC
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI 5'-METHYLTHIOADENOSINE/S-ADENOSYL HOMOCYSTEINE NUCLEOSIDASE (MTAN) COMPLEXED WITH BUTYLTHIO-DADME-IMMUCILLIN-A
分子名称:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-ol, TETRAETHYLENE GLYCOL
著者Cameron, S.A., Thomas, K., Almo, S.C., Schramm, V.L.
登録日2014-10-02
公開日2015-08-19
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Active site and remote contributions to catalysis in methylthioadenosine nucleosidases.
Biochemistry, 54, 2015
4YML
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI 5'-METHYLTHIOADENOSINE/S-ADENOSYL HOMOCYSTEINE NUCLEOSIDASE (MTAN) COMPLEXED WITH (3S,4R)-METHYLTHIO-DADME-IMMUCILLIN-A
分子名称:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, (3S,4R)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol, PHOSPHATE ION
著者Cameron, S.A., Thomas, K., Almo, S.C., Schramm, V.L.
登録日2015-03-06
公開日2015-08-26
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Tight binding enantiomers of pre-clinical drug candidates.
Bioorg.Med.Chem., 23, 2015