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1RR6

Structure of human purine nucleoside phosphorylase in complex with Immucillin-H and phosphate

Summary for 1RR6
Entry DOI10.2210/pdb1rr6/pdb
Related1RSZ 1RT9
DescriptorPurine nucleoside phosphorylase, PHOSPHATE ION, 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, ... (4 entities in total)
Functional Keywordspnp, transition state analogue, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton (By similarity): P00491
Total number of polymer chains1
Total formula weight32736.04
Authors
Shi, W.,Lewandowicz, A.,Tyler, P.C.,Furneaux, R.H.,Almo, S.C.,Schramm, V.L. (deposition date: 2003-12-08, release date: 2005-02-22, Last modification date: 2023-09-20)
Primary citationShi, W.,Ting, L.M.,Kicska, G.A.,Lewandowicz, A.,Tyler, P.C.,Evans, G.B.,Furneaux, R.H.,Kim, K.,Almo, S.C.,Schramm, V.L.
Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function.
J.Biol.Chem., 279:18103-18106, 2004
Cited by
PubMed: 14982926
DOI: 10.1074/jbc.C400068200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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