1RR6
Structure of human purine nucleoside phosphorylase in complex with Immucillin-H and phosphate
Summary for 1RR6
Entry DOI | 10.2210/pdb1rr6/pdb |
Related | 1RSZ 1RT9 |
Descriptor | Purine nucleoside phosphorylase, PHOSPHATE ION, 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, ... (4 entities in total) |
Functional Keywords | pnp, transition state analogue, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton (By similarity): P00491 |
Total number of polymer chains | 1 |
Total formula weight | 32736.04 |
Authors | Shi, W.,Lewandowicz, A.,Tyler, P.C.,Furneaux, R.H.,Almo, S.C.,Schramm, V.L. (deposition date: 2003-12-08, release date: 2005-02-22, Last modification date: 2023-09-20) |
Primary citation | Shi, W.,Ting, L.M.,Kicska, G.A.,Lewandowicz, A.,Tyler, P.C.,Evans, G.B.,Furneaux, R.H.,Kim, K.,Almo, S.C.,Schramm, V.L. Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function. J.Biol.Chem., 279:18103-18106, 2004 Cited by PubMed: 14982926DOI: 10.1074/jbc.C400068200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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