1CJB
MALARIAL PURINE PHOSPHORIBOSYLTRANSFERASE
Summary for 1CJB
Entry DOI | 10.2210/pdb1cjb/pdb |
Descriptor | PROTEIN (HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE), MAGNESIUM ION, (1S)-1(9-DEAZAHYPOXANTHIN-9YL)1,4-DIDEOXY-1,4-IMINO-D-RIBITOL-5-PHOSPHATE, ... (5 entities in total) |
Functional Keywords | malaria, purine salvage, phosphoribosyltransferase, transition state inhibitor, transferase |
Biological source | Plasmodium falciparum (malaria parasite P. falciparum) |
Total number of polymer chains | 4 |
Total formula weight | 107829.04 |
Authors | Shi, W.,Li, C.M.,Tyler, P.C.,Furneaux, R.H.,Cahill, S.M.,Girvin, M.E.,Grubmeyer, C.,Schramm, V.L.,Almo, S.C. (deposition date: 1999-04-08, release date: 1999-08-18, Last modification date: 2023-08-09) |
Primary citation | Shi, W.,Li, C.M.,Tyler, P.C.,Furneaux, R.H.,Cahill, S.M.,Girvin, M.E.,Grubmeyer, C.,Schramm, V.L.,Almo, S.C. The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor. Biochemistry, 38:9872-9880, 1999 Cited by PubMed: 10433693DOI: 10.1021/bi990664p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report