Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1CJB

MALARIAL PURINE PHOSPHORIBOSYLTRANSFERASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0000310	molecular_function	xanthine phosphoribosyltransferase activity
A	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0006178	biological_process	guanine salvage
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0032263	biological_process	GMP salvage
A	0032264	biological_process	IMP salvage
A	0032265	biological_process	XMP salvage
A	0046100	biological_process	hypoxanthine metabolic process
A	0046872	molecular_function	metal ion binding
A	0052657	molecular_function	guanine phosphoribosyltransferase activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0000310	molecular_function	xanthine phosphoribosyltransferase activity
B	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006166	biological_process	purine ribonucleoside salvage
B	0006178	biological_process	guanine salvage
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0032263	biological_process	GMP salvage
B	0032264	biological_process	IMP salvage
B	0032265	biological_process	XMP salvage
B	0046100	biological_process	hypoxanthine metabolic process
B	0046872	molecular_function	metal ion binding
B	0052657	molecular_function	guanine phosphoribosyltransferase activity
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0000310	molecular_function	xanthine phosphoribosyltransferase activity
C	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006166	biological_process	purine ribonucleoside salvage
C	0006178	biological_process	guanine salvage
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0032263	biological_process	GMP salvage
C	0032264	biological_process	IMP salvage
C	0032265	biological_process	XMP salvage
C	0046100	biological_process	hypoxanthine metabolic process
C	0046872	molecular_function	metal ion binding
C	0052657	molecular_function	guanine phosphoribosyltransferase activity
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0000310	molecular_function	xanthine phosphoribosyltransferase activity
D	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006166	biological_process	purine ribonucleoside salvage
D	0006178	biological_process	guanine salvage
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0032263	biological_process	GMP salvage
D	0032264	biological_process	IMP salvage
D	0032265	biological_process	XMP salvage
D	0046100	biological_process	hypoxanthine metabolic process
D	0046872	molecular_function	metal ion binding
D	0052657	molecular_function	guanine phosphoribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 405

Chain	Residue
A	IRP300
A	POP400
A	HOH516
A	HOH603

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 406

Chain	Residue
A	ASP204
A	POP400
A	HOH542
A	HOH616
A	HOH664

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 405

Chain	Residue
B	IRP300
B	POP400
B	HOH547
B	HOH557

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 406

Chain	Residue
B	ASP204
B	POP400
B	HOH507
B	HOH548
B	HOH552

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 405

Chain	Residue
C	IRP300
C	POP400
C	HOH641
C	HOH651

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 406

Chain	Residue
C	ASP204
C	POP400
C	HOH535
C	HOH554
C	HOH585

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 405

Chain	Residue
D	IRP300
D	POP400
D	HOH562
D	HOH685

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 406

Chain	Residue
D	ASP204
D	POP400
D	HOH517
D	HOH596
D	HOH612

site_id	AC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE IRP A 300

Chain	Residue
A	TYR116
A	GLU144
A	ASP145
A	ILE146
A	ASP148
A	THR149
A	GLY150
A	LYS151
A	THR152
A	LYS176
A	PHE197
A	VAL198
A	ASP204
A	POP400
A	MG405
A	HOH503
A	HOH505
A	HOH616

site_id	BC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE POP A 400

Chain	Residue
A	LYS77
A	GLY78
A	ARG112
A	VAL113
A	LYS114
A	SER115
A	TYR116
A	ASP204
A	ARG210
A	IRP300
A	MG405
A	MG406
A	HOH516
A	HOH543
A	HOH603
A	HOH616
A	HOH664

site_id	BC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE IRP B 300

Chain	Residue
B	TYR116
B	GLU144
B	ASP145
B	ILE146
B	ASP148
B	THR149
B	GLY150
B	LYS151
B	THR152
B	LYS176
B	PHE197
B	VAL198
B	ASP204
B	POP400
B	MG405
B	HOH502
B	HOH515
B	HOH547
B	HOH548

site_id	BC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE POP B 400

Chain	Residue
B	ARG210
B	IRP300
B	MG405
B	MG406
B	HOH507
B	HOH723
B	LEU76
B	LYS77
B	GLY78
B	ARG112
B	VAL113
B	LYS114
B	SER115
B	TYR116
B	ASP204

site_id	BC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE IRP C 300

Chain	Residue
C	TYR116
C	GLU144
C	ASP145
C	ILE146
C	ASP148
C	THR149
C	GLY150
C	LYS151
C	THR152
C	LYS176
C	PHE197
C	VAL198
C	LEU203
C	ASP204
C	POP400
C	MG405
C	HOH508
C	HOH535
C	HOH599

site_id	BC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE POP C 400

Chain	Residue
C	LYS77
C	GLY78
C	ARG112
C	LYS114
C	SER115
C	TYR116
C	ASP204
C	ARG210
C	IRP300
C	MG405
C	MG406
C	HOH531
C	HOH534
C	HOH585
C	HOH867

site_id	BC6
Number of Residues	19
Details	BINDING SITE FOR RESIDUE IRP D 300

Chain	Residue
D	TYR116
D	GLU144
D	ASP145
D	ILE146
D	ASP148
D	THR149
D	GLY150
D	LYS151
D	THR152
D	LYS176
D	PHE197
D	VAL198
D	LEU203
D	ASP204
D	POP400
D	MG405
D	HOH517
D	HOH569
D	HOH579

site_id	BC7
Number of Residues	17
Details	BINDING SITE FOR RESIDUE POP D 400

Chain	Residue
D	LYS77
D	GLY78
D	ARG112
D	VAL113
D	LYS114
D	SER115
D	TYR116
D	ASP204
D	ARG210
D	IRP300
D	MG405
D	MG406
D	HOH562
D	HOH612
D	HOH638
D	HOH685
D	HOH894

Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIIDTGkT

Chain	Residue	Details
A	VAL140-THR152

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	40
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10433693","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
A	ASP145
A	ASP148
A	GLU144
A	LYS176

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
B	ASP145
B	ASP148
B	GLU144
B	LYS176

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
C	ASP145
C	ASP148
C	GLU144
C	LYS176

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
D	ASP145
D	ASP148
D	GLU144
D	LYS176

site_id	CSA5
Number of Residues	5
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
A	ASP145
A	ASP148
A	LEU180
A	GLU144
A	LYS176

site_id	CSA6
Number of Residues	5
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
B	ASP145
B	ASP148
B	LEU180
B	GLU144
B	LYS176

site_id	CSA7
Number of Residues	5
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
C	ASP145
C	ASP148
C	LEU180
C	GLU144
C	LYS176

site_id	CSA8
Number of Residues	5
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
D	ASP145
D	ASP148
D	LEU180
D	GLU144
D	LYS176

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)