1BZY

HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR

Summary for 1BZY

Entry DOI	10.2210/pdb1bzy/pdb
Descriptor	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, PHOSPHORIC ACID MONO-[5-(2-AMINO-4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXY-PYRROLIDIN-2-YLMETHYL] ESTER, ... (5 entities in total)
Functional Keywords	phosphoribosyltransferase, immucillin, lesch-nyhan, hgprt, transition state, magnesium, pyrophosphate, oxocarbenium ion, neighboring group participation
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00492
Total number of polymer chains	4
Total formula weight	100268.14
Authors	Shi, W.,Li, C.,Tyler, P.C.,Furneaux, R.H.,Grubmeyer, C.,Schramm, V.L.,Almo, S.C. (deposition date: 1998-11-05, release date: 1999-06-22, Last modification date: 2023-08-09)
Primary citation	Shi, W.,Li, C.M.,Tyler, P.C.,Furneaux, R.H.,Grubmeyer, C.,Schramm, V.L.,Almo, S.C. The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor. Nat.Struct.Biol., 6:588-593, 1999 Cited by PubMed: 10360366 DOI: 10.1038/9376 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation