4YML

Crystal structure of Escherichia coli 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3S,4R)-methylthio-DADMe-Immucillin-A

Summary for 4YML

Entry DOI	10.2210/pdb4yml/pdb
Related	1Y6Q 4WKC
Descriptor	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, (3S,4R)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	26447.06
Authors	Cameron, S.A.,Thomas, K.,Almo, S.C.,Schramm, V.L. (deposition date: 2015-03-06, release date: 2015-08-26, Last modification date: 2023-09-27)
Primary citation	Evans, G.B.,Cameron, S.A.,Luxenburger, A.,Guan, R.,Suarez, J.,Thomas, K.,Schramm, V.L.,Tyler, P.C. Tight binding enantiomers of pre-clinical drug candidates. Bioorg.Med.Chem., 23:5326-5333, 2015 Cited by PubMed: 26260335 DOI: 10.1016/j.bmc.2015.07.059 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation