4YML
Crystal structure of Escherichia coli 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3S,4R)-methylthio-DADMe-Immucillin-A
Summary for 4YML
Entry DOI | 10.2210/pdb4yml/pdb |
Related | 1Y6Q 4WKC |
Descriptor | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, (3S,4R)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 26447.06 |
Authors | Cameron, S.A.,Thomas, K.,Almo, S.C.,Schramm, V.L. (deposition date: 2015-03-06, release date: 2015-08-26, Last modification date: 2023-09-27) |
Primary citation | Evans, G.B.,Cameron, S.A.,Luxenburger, A.,Guan, R.,Suarez, J.,Thomas, K.,Schramm, V.L.,Tyler, P.C. Tight binding enantiomers of pre-clinical drug candidates. Bioorg.Med.Chem., 23:5326-5333, 2015 Cited by PubMed: 26260335DOI: 10.1016/j.bmc.2015.07.059 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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