4WKC
Crystal structure of Escherichia coli 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with butylthio-DADMe-Immucillin-A
Summary for 4WKC
Entry DOI | 10.2210/pdb4wkc/pdb |
Related | 1Y6Q 4WKN 4WKO 4WKP |
Descriptor | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-ol, TETRAETHYLENE GLYCOL, ... (4 entities in total) |
Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Escherichia coli O139:H28 |
Total number of polymer chains | 1 |
Total formula weight | 26588.40 |
Authors | Cameron, S.A.,Thomas, K.,Almo, S.C.,Schramm, V.L. (deposition date: 2014-10-02, release date: 2015-08-19, Last modification date: 2023-09-27) |
Primary citation | Thomas, K.,Cameron, S.A.,Almo, S.C.,Burgos, E.S.,Gulab, S.A.,Schramm, V.L. Active site and remote contributions to catalysis in methylthioadenosine nucleosidases. Biochemistry, 54:2520-2529, 2015 Cited by PubMed: 25806409DOI: 10.1021/bi501487w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.64 Å) |
Structure validation
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