2ISC

Crystal structure of Purine Nucleoside Phosphorylase from Trichomonas vaginalis with DADMe-Imm-A

Summary for 2ISC

Entry DOI	10.2210/pdb2isc/pdb
Related	2I4T
Descriptor	purine nucleoside phosphorylase, PHOSPHATE ION, (3R,4R)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-(HYDROXYMETHYL)PYRROLIDIN-3-OL, ... (4 entities in total)
Functional Keywords	purine nucleoside phosphorylase, transferase
Biological source	Trichomonas vaginalis
Total number of polymer chains	6
Total formula weight	160537.02
Authors	Rinaldo-Matthis, A.,Almo, S.C.,Schramm, V.L. (deposition date: 2006-10-17, release date: 2007-06-05, Last modification date: 2024-02-21)
Primary citation	Rinaldo-Matthis, A.,Wing, C.,Ghanem, M.,Deng, H.,Wu, P.,Gupta, A.,Tyler, P.C.,Evans, G.B.,Furneaux, R.H.,Almo, S.C.,Wang, C.C.,Schramm, V.L. Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues Biochemistry, 46:659-668, 2007 Cited by PubMed: 17223688 DOI: 10.1021/bi061515r PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation