2ISC
Crystal structure of Purine Nucleoside Phosphorylase from Trichomonas vaginalis with DADMe-Imm-A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006218 | biological_process | uridine catabolic process |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| B | 0004850 | molecular_function | uridine phosphorylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0006218 | biological_process | uridine catabolic process |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| C | 0004850 | molecular_function | uridine phosphorylase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| C | 0006218 | biological_process | uridine catabolic process |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| D | 0004850 | molecular_function | uridine phosphorylase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| D | 0006218 | biological_process | uridine catabolic process |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| E | 0004850 | molecular_function | uridine phosphorylase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| E | 0006218 | biological_process | uridine catabolic process |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016757 | molecular_function | glycosyltransferase activity |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| F | 0004850 | molecular_function | uridine phosphorylase activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| F | 0006218 | biological_process | uridine catabolic process |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016757 | molecular_function | glycosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 F 9003 |
| Chain | Residue |
| D | ARG43 |
| F | GLY20 |
| F | ARG87 |
| F | GLY89 |
| F | THR90 |
| F | 223404 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 D 9001 |
| Chain | Residue |
| D | GLY89 |
| D | THR90 |
| D | 223403 |
| F | ARG43 |
| D | GLY20 |
| D | ARG24 |
| D | ARG87 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 E 9002 |
| Chain | Residue |
| C | ARG43 |
| E | GLY20 |
| E | ARG24 |
| E | ARG87 |
| E | GLY89 |
| E | THR90 |
| E | 223400 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 B 9004 |
| Chain | Residue |
| A | ARG43 |
| B | GLY20 |
| B | ARG24 |
| B | ARG87 |
| B | GLY89 |
| B | THR90 |
| B | 223402 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 9005 |
| Chain | Residue |
| A | GLY20 |
| A | ARG24 |
| A | ARG87 |
| A | GLY89 |
| A | THR90 |
| A | 223401 |
| B | ARG43 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 C 9006 |
| Chain | Residue |
| C | GLY20 |
| C | ARG24 |
| C | ARG87 |
| C | GLY89 |
| C | THR90 |
| C | 223405 |
| E | ARG43 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 A 9007 |
| Chain | Residue |
| A | ASP122 |
| D | ASP122 |
| E | ASP122 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 9009 |
| Chain | Residue |
| B | ARG195 |
| B | LYS234 |
| B | LEU235 |
| B | HIS236 |
| B | HOH9025 |
| B | HOH9031 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 223 B 402 |
| Chain | Residue |
| A | HIS4 |
| A | ARG43 |
| B | MET64 |
| B | THR90 |
| B | CYS91 |
| B | GLY92 |
| B | PHE159 |
| B | VAL178 |
| B | GLU179 |
| B | MET180 |
| B | GLU181 |
| B | SER203 |
| B | ASP204 |
| B | ILE206 |
| B | PO49004 |
| site_id | BC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 223 D 403 |
| Chain | Residue |
| D | MET64 |
| D | THR90 |
| D | CYS91 |
| D | GLY92 |
| D | PHE159 |
| D | VAL178 |
| D | GLU179 |
| D | GLU181 |
| D | SER203 |
| D | ASP204 |
| D | PO49001 |
| D | HOH9015 |
| D | HOH9031 |
| F | HIS4 |
| site_id | BC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 223 F 404 |
| Chain | Residue |
| D | HIS4 |
| D | ARG43 |
| F | MET64 |
| F | THR90 |
| F | CYS91 |
| F | GLY92 |
| F | PHE159 |
| F | VAL178 |
| F | GLU179 |
| F | GLU181 |
| F | SER203 |
| F | ASP204 |
| F | PO49003 |
| F | HOH9021 |
| site_id | BC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 223 C 405 |
| Chain | Residue |
| C | GLU179 |
| C | GLU181 |
| C | ASP204 |
| C | PO49006 |
| C | HOH9013 |
| E | HIS4 |
| E | ARG43 |
| C | MET64 |
| C | THR90 |
| C | CYS91 |
| C | GLY92 |
| C | PHE159 |
| C | VAL178 |
| site_id | BC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 223 A 401 |
| Chain | Residue |
| A | MET64 |
| A | THR90 |
| A | CYS91 |
| A | GLY92 |
| A | PHE159 |
| A | VAL178 |
| A | GLU179 |
| A | MET180 |
| A | GLU181 |
| A | SER203 |
| A | ASP204 |
| A | PO49005 |
| A | HOH9024 |
| A | HOH9028 |
| B | HIS4 |
| site_id | BC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 223 E 400 |
| Chain | Residue |
| C | HIS4 |
| C | ARG43 |
| E | MET64 |
| E | THR90 |
| E | CYS91 |
| E | GLY92 |
| E | PHE159 |
| E | VAL178 |
| E | GLU179 |
| E | GLU181 |
| E | SER203 |
| E | ASP204 |
| E | PO49002 |
| E | HOH9017 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a69 |
| Chain | Residue | Details |
| A | ASP204 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a69 |
| Chain | Residue | Details |
| B | ASP204 | |
| B | ARG217 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a69 |
| Chain | Residue | Details |
| C | ASP204 | |
| C | ARG217 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a69 |
| Chain | Residue | Details |
| D | ASP204 | |
| D | ARG217 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a69 |
| Chain | Residue | Details |
| E | ASP204 | |
| E | ARG217 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a69 |
| Chain | Residue | Details |
| F | ASP204 | |
| F | ARG217 |
