1Q1G

Crystal structure of Plasmodium falciparum PNP with 5'-methylthio-immucillin-H

Summary for 1Q1G

• Entry DOI: 10.2210/pdb1q1g/pdb
• Related: 1NW4
• Descriptor: Uridine phosphorylase putative, SULFATE ION, 3,4-DIHYDROXY-2-[(METHYLSULFANYL)METHYL]-5-(4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)PYRROLIDINIUM, ... (5 entities in total)
• Functional Keywords: transition state complex, transferase
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 6
• Total formula weight: 187450.59

Authors

Shi, W.,Ting, L.M.,Kicska, G.A.,Lewandowicz, A.,Tyler, P.C.,Evans, G.B.,Furneaux, R.H.,Kim, K.,Almo, S.C.,Schramm, V.L. (deposition date: 2003-07-19, release date: 2004-03-16, Last modification date: 2023-08-16)

• Primary citation: Shi, W.,Ting, L.M.,Kicska, G.A.,Lewandowicz, A.,Tyler, P.C.,Evans, G.B.,Furneaux, R.H.,Kim, K.,Almo, S.C.,Schramm, V.L.; Plasmodium falciparum Purine Nucleoside Phosphorylase: CRYSTAL STRUCTURES, IMMUCILLIN INHIBITORS, AND DUAL CATALYTIC FUNCTION.; J.Biol.Chem., 279:18103-18106, 2004; PubMed: 14982926; DOI: 10.1074/jbc.C400068200

Experimental method

X-RAY DIFFRACTION (2.02 Å)