1ZOS
Structure of 5'-methylthionadenosine/S-Adenosylhomocysteine nucleosidase from S. pneumoniae with a transition-state inhibitor MT-ImmA
Summary for 1ZOS
Entry DOI | 10.2210/pdb1zos/pdb |
Descriptor | 5'-methylthioadenosine / S-adenosylhomocysteine nucleosidase, (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL (3 entities in total) |
Functional Keywords | nucleosidase, pneumoniae, transition state, inhibitor, hydrolase |
Biological source | Streptococcus pneumoniae R6 |
Total number of polymer chains | 6 |
Total formula weight | 149983.92 |
Authors | Shi, W.,Singh, V.,Zhen, R.,Tyler, P.C.,Furneaux, R.H.,Almo, S.C.,Schramm, V.L. (deposition date: 2005-05-13, release date: 2006-04-25, Last modification date: 2023-08-23) |
Primary citation | Singh, V.,Shi, W.,Almo, S.C.,Evans, G.B.,Furneaux, R.H.,Tyler, P.C.,Painter, G.F.,Lenz, D.H.,Mee, S.,Zheng, R.,Schramm, V.L. Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae. Biochemistry, 45:12929-12941, 2006 Cited by PubMed: 17059210DOI: 10.1021/bi061184i PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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