1ZOS

Structure of 5'-methylthionadenosine/S-Adenosylhomocysteine nucleosidase from S. pneumoniae with a transition-state inhibitor MT-ImmA

Summary for 1ZOS

• Entry DOI: 10.2210/pdb1zos/pdb
• Descriptor: 5'-methylthioadenosine / S-adenosylhomocysteine nucleosidase, (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL (3 entities in total)
• Functional Keywords: nucleosidase, pneumoniae, transition state, inhibitor, hydrolase
• Biological source: Streptococcus pneumoniae R6
• Total number of polymer chains: 6
• Total formula weight: 149983.92

Authors

Shi, W.,Singh, V.,Zhen, R.,Tyler, P.C.,Furneaux, R.H.,Almo, S.C.,Schramm, V.L. (deposition date: 2005-05-13, release date: 2006-04-25, Last modification date: 2023-08-23)

• Primary citation: Singh, V.,Shi, W.,Almo, S.C.,Evans, G.B.,Furneaux, R.H.,Tyler, P.C.,Painter, G.F.,Lenz, D.H.,Mee, S.,Zheng, R.,Schramm, V.L.; Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae.; Biochemistry, 45:12929-12941, 2006; PubMed: 17059210; DOI: 10.1021/bi061184i

Experimental method

X-RAY DIFFRACTION (1.6 Å)