Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1ZOS

Structure of 5'-methylthionadenosine/S-Adenosylhomocysteine nucleosidase from S. pneumoniae with a transition-state inhibitor MT-ImmA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
A	0008930	molecular_function	methylthioadenosine nucleosidase activity
A	0009086	biological_process	methionine biosynthetic process
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
A	0019509	biological_process	L-methionine salvage from methylthioadenosine
B	0003824	molecular_function	catalytic activity
B	0005829	cellular_component	cytosol
B	0008652	biological_process	amino acid biosynthetic process
B	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
B	0008930	molecular_function	methylthioadenosine nucleosidase activity
B	0009086	biological_process	methionine biosynthetic process
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
B	0019509	biological_process	L-methionine salvage from methylthioadenosine
C	0003824	molecular_function	catalytic activity
C	0005829	cellular_component	cytosol
C	0008652	biological_process	amino acid biosynthetic process
C	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
C	0008930	molecular_function	methylthioadenosine nucleosidase activity
C	0009086	biological_process	methionine biosynthetic process
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
C	0019509	biological_process	L-methionine salvage from methylthioadenosine
D	0003824	molecular_function	catalytic activity
D	0005829	cellular_component	cytosol
D	0008652	biological_process	amino acid biosynthetic process
D	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
D	0008930	molecular_function	methylthioadenosine nucleosidase activity
D	0009086	biological_process	methionine biosynthetic process
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0016787	molecular_function	hydrolase activity
D	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
D	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
D	0019509	biological_process	L-methionine salvage from methylthioadenosine
E	0003824	molecular_function	catalytic activity
E	0005829	cellular_component	cytosol
E	0008652	biological_process	amino acid biosynthetic process
E	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
E	0008930	molecular_function	methylthioadenosine nucleosidase activity
E	0009086	biological_process	methionine biosynthetic process
E	0009116	biological_process	nucleoside metabolic process
E	0009164	biological_process	nucleoside catabolic process
E	0016787	molecular_function	hydrolase activity
E	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
E	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
E	0019509	biological_process	L-methionine salvage from methylthioadenosine
F	0003824	molecular_function	catalytic activity
F	0005829	cellular_component	cytosol
F	0008652	biological_process	amino acid biosynthetic process
F	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
F	0008930	molecular_function	methylthioadenosine nucleosidase activity
F	0009086	biological_process	methionine biosynthetic process
F	0009116	biological_process	nucleoside metabolic process
F	0009164	biological_process	nucleoside catabolic process
F	0016787	molecular_function	hydrolase activity
F	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
F	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
F	0019509	biological_process	L-methionine salvage from methylthioadenosine

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE MTM A 301

Chain	Residue
A	ALA8
A	MET173
A	GLU174
A	ARG193
A	SER196
A	ASP197
A	ALA199
A	PHE207
A	HOH607
A	ILE50
A	SER76
A	ALA77
A	GLY78
A	SER150
A	PHE151
A	VAL152
A	GLU172

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE MTM B 302

Chain	Residue
B	ALA8
B	ILE50
B	SER76
B	ALA77
B	GLY78
B	SER150
B	PHE151
B	VAL152
B	GLU172
B	MET173
B	GLU174
B	ARG193
B	SER196
B	ASP197
B	ALA199
B	PHE207
B	HOH380

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE MTM C 303

Chain	Residue
C	ALA8
C	SER76
C	ALA77
C	GLY78
C	SER150
C	PHE151
C	VAL152
C	GLU172
C	MET173
C	GLU174
C	ARG193
C	SER196
C	ASP197
C	ALA199
C	PHE207
C	HOH422
D	PHE105

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MTM D 304

Chain	Residue
D	ALA8
D	SER76
D	ALA77
D	GLY78
D	SER150
D	PHE151
D	VAL152
D	GLU172
D	MET173
D	GLU174
D	ARG193
D	SER196
D	ASP197
D	ALA199
D	PHE207
D	HOH443

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MTM E 305

Chain	Residue
E	ALA8
E	SER76
E	ALA77
E	GLY78
E	SER150
E	PHE151
E	VAL152
E	GLU172
E	MET173
E	GLU174
E	ARG193
E	SER196
E	ASP197
E	ALA199
E	PHE207
E	HOH413

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE MTM F 306

Chain	Residue
F	HOH411
E	PHE105
F	ALA8
F	SER76
F	ALA77
F	GLY78
F	SER150
F	PHE151
F	VAL152
F	GLU172
F	MET173
F	GLU174
F	ARG193
F	SER196
F	ASP197
F	ALA199
F	PHE207

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a69

Chain	Residue	Details
A	ASP197
A	PHE210

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a69

Chain	Residue	Details
B	ASP197
B	PHE210

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1a69

Chain	Residue	Details
C	ASP197
C	PHE210

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1a69

Chain	Residue	Details
D	ASP197
D	PHE210

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1a69

Chain	Residue	Details
E	ASP197
E	PHE210

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1a69

Chain	Residue	Details
F	ASP197
F	PHE210

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)