1ZOS
Structure of 5'-methylthionadenosine/S-Adenosylhomocysteine nucleosidase from S. pneumoniae with a transition-state inhibitor MT-ImmA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| A | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0019509 | biological_process | obsolete L-methionine salvage from methylthioadenosine |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| B | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0019509 | biological_process | obsolete L-methionine salvage from methylthioadenosine |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| C | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0009164 | biological_process | nucleoside catabolic process |
| C | 0019509 | biological_process | obsolete L-methionine salvage from methylthioadenosine |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| D | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0009164 | biological_process | nucleoside catabolic process |
| D | 0019509 | biological_process | obsolete L-methionine salvage from methylthioadenosine |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| E | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0009164 | biological_process | nucleoside catabolic process |
| E | 0019509 | biological_process | obsolete L-methionine salvage from methylthioadenosine |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| F | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0009164 | biological_process | nucleoside catabolic process |
| F | 0019509 | biological_process | obsolete L-methionine salvage from methylthioadenosine |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE MTM A 301 |
| Chain | Residue |
| A | ALA8 |
| A | MET173 |
| A | GLU174 |
| A | ARG193 |
| A | SER196 |
| A | ASP197 |
| A | ALA199 |
| A | PHE207 |
| A | HOH607 |
| A | ILE50 |
| A | SER76 |
| A | ALA77 |
| A | GLY78 |
| A | SER150 |
| A | PHE151 |
| A | VAL152 |
| A | GLU172 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE MTM B 302 |
| Chain | Residue |
| B | ALA8 |
| B | ILE50 |
| B | SER76 |
| B | ALA77 |
| B | GLY78 |
| B | SER150 |
| B | PHE151 |
| B | VAL152 |
| B | GLU172 |
| B | MET173 |
| B | GLU174 |
| B | ARG193 |
| B | SER196 |
| B | ASP197 |
| B | ALA199 |
| B | PHE207 |
| B | HOH380 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE MTM C 303 |
| Chain | Residue |
| C | ALA8 |
| C | SER76 |
| C | ALA77 |
| C | GLY78 |
| C | SER150 |
| C | PHE151 |
| C | VAL152 |
| C | GLU172 |
| C | MET173 |
| C | GLU174 |
| C | ARG193 |
| C | SER196 |
| C | ASP197 |
| C | ALA199 |
| C | PHE207 |
| C | HOH422 |
| D | PHE105 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE MTM D 304 |
| Chain | Residue |
| D | ALA8 |
| D | SER76 |
| D | ALA77 |
| D | GLY78 |
| D | SER150 |
| D | PHE151 |
| D | VAL152 |
| D | GLU172 |
| D | MET173 |
| D | GLU174 |
| D | ARG193 |
| D | SER196 |
| D | ASP197 |
| D | ALA199 |
| D | PHE207 |
| D | HOH443 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE MTM E 305 |
| Chain | Residue |
| E | ALA8 |
| E | SER76 |
| E | ALA77 |
| E | GLY78 |
| E | SER150 |
| E | PHE151 |
| E | VAL152 |
| E | GLU172 |
| E | MET173 |
| E | GLU174 |
| E | ARG193 |
| E | SER196 |
| E | ASP197 |
| E | ALA199 |
| E | PHE207 |
| E | HOH413 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE MTM F 306 |
| Chain | Residue |
| F | HOH411 |
| E | PHE105 |
| F | ALA8 |
| F | SER76 |
| F | ALA77 |
| F | GLY78 |
| F | SER150 |
| F | PHE151 |
| F | VAL152 |
| F | GLU172 |
| F | MET173 |
| F | GLU174 |
| F | ARG193 |
| F | SER196 |
| F | ASP197 |
| F | ALA199 |
| F | PHE207 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a69 |
| Chain | Residue | Details |
| A | ASP197 | |
| A | PHE210 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a69 |
| Chain | Residue | Details |
| B | ASP197 | |
| B | PHE210 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a69 |
| Chain | Residue | Details |
| C | ASP197 | |
| C | PHE210 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a69 |
| Chain | Residue | Details |
| D | ASP197 | |
| D | PHE210 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a69 |
| Chain | Residue | Details |
| E | ASP197 | |
| E | PHE210 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a69 |
| Chain | Residue | Details |
| F | ASP197 | |
| F | PHE210 |
