1K27

Crystal Structure of 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with a Transition State Analogue

Summary for 1K27

• Entry DOI: 10.2210/pdb1k27/pdb
• Descriptor: 5'-Deoxy-5'-Methylthioadenosine Phosphorylase, PHOSPHATE ION, (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL, ... (4 entities in total)
• Functional Keywords: mtap, methylthioadenosine phosphorylase, transition state analogue, phosphate, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q13126
• Total number of polymer chains: 1
• Total formula weight: 31669.40

Authors

Shi, W.,Singh, V.,Tyler, P.C.,Furneaux, R.H.,Almo, S.C.,Schramm, V.L. (deposition date: 2001-09-26, release date: 2003-09-30, Last modification date: 2023-08-16)

• Primary citation: Singh, V.,Shi, W.,Evans, G.B.,Tyler, P.C.,Furneaux, R.H.,Almo, S.C.,Schramm, V.L.; Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A; Biochemistry, 43:9-18, 2004; PubMed: 14705926

Experimental method

X-RAY DIFFRACTION (1.95 Å)