1N3I

Crystal Structure of Mycobacterium tuberculosis PNP with transition state analog DADMe-ImmH

Summary for 1N3I

Related1G2O
DescriptorPurine Nucleoside Phosphorylase, PHOSPHATE ION, 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, ... (4 entities in total)
Functional Keywordstransition state complex, trimer, pnp, transferase
Biological sourceMycobacterium tuberculosis
Total number of polymer chains3
Total molecular weight83879.15
Authors
Lewandowicz, A.,Shi, W.,Evans, G.B.,Tyler, P.C.,Furneaux, R.H.,Basso, L.A.,Santos, D.S.,Almo, S.C.,Schramm, V.L. (deposition date: 2002-10-28, release date: 2003-09-30, Last modification date: 2018-12-19)
Primary citation
Lewandowicz, A.,Shi, W.,Evans, G.B.,Tyler, P.C.,Furneaux, R.H.,Basso, L.A.,Santos, D.S.,Almo, S.C.,Schramm, V.L.
Over-The-Barrier Transition State Analogues Provide New Chemistries for Inhibitor Design: The Case of Purine Nucleoside Phosphorylase
BIOCHEMISTRY, 42:6057-6066, 2003
PubMed: 12755607 (PDB entries with the same primary citation)
DOI: 10.1021/bi0343830
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers6 0.1% 1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-11-25