1N3I

Crystal Structure of Mycobacterium tuberculosis PNP with transition state analog DADMe-ImmH

Summary for 1N3I

• Entry DOI: 10.2210/pdb1n3i/pdb
• Related: 1G2O
• Descriptor: Purine Nucleoside Phosphorylase, PHOSPHATE ION, 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, ... (4 entities in total)
• Functional Keywords: transition state complex, trimer, pnp, transferase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 3
• Total formula weight: 83879.15

Authors

Lewandowicz, A.,Shi, W.,Evans, G.B.,Tyler, P.C.,Furneaux, R.H.,Basso, L.A.,Santos, D.S.,Almo, S.C.,Schramm, V.L. (deposition date: 2002-10-28, release date: 2003-09-30, Last modification date: 2023-10-25)

• Primary citation: Lewandowicz, A.,Shi, W.,Evans, G.B.,Tyler, P.C.,Furneaux, R.H.,Basso, L.A.,Santos, D.S.,Almo, S.C.,Schramm, V.L.; Over-The-Barrier Transition State Analogues Provide New Chemistries for Inhibitor Design: The Case of Purine Nucleoside Phosphorylase; BIOCHEMISTRY, 42:6057-6066, 2003; PubMed: 12755607; DOI: 10.1021/bi0343830

Experimental method

X-RAY DIFFRACTION (1.9 Å)