1G2O

CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH A TRANSITION-STATE INHIBITOR

Summary for 1G2O

Entry DOI	10.2210/pdb1g2o/pdb
Descriptor	PURINE NUCLEOSIDE PHOSPHORYLASE, PHOSPHATE ION, 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, ... (4 entities in total)
Functional Keywords	trimer, transition-state complex, transferase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	3
Total formula weight	83882.04
Authors	Shi, W.,Basso, L.A.,Tyler, P.C.,Furneaux, R.H.,Blanchard, J.S.,Almo, S.C.,Schramm, V.L. (deposition date: 2000-10-20, release date: 2001-08-01, Last modification date: 2023-09-20)
Primary citation	Shi, W.,Basso, L.A.,Santos, D.S.,Tyler, P.C.,Furneaux, R.H.,Blanchard, J.S.,Almo, S.C.,Schramm, V.L. Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces. Biochemistry, 40:8204-8215, 2001 Cited by PubMed: 11444966 DOI: 10.1021/bi010585p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation