3BGS

Structure of human purine nucleoside phosphorylase with L-DADMe-ImmH and phosphate

Summary for 3BGS

Entry DOI	10.2210/pdb3bgs/pdb
Related	1RR6 1RSZ 1RT9
Descriptor	purine nucleoside phosphorylase, PHOSPHATE ION, 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, ... (4 entities in total)
Functional Keywords	pnp, transition state analogue, l-enantiomer, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	32735.08
Authors	Murkin, A.S.,Ramagopal, U.A.,Almo, S.C.,Schramm, V.L. (deposition date: 2007-11-27, release date: 2008-01-08, Last modification date: 2023-08-30)
Primary citation	Rinaldo-Matthis, A.,Murkin, A.S.,Ramagopal, U.A.,Clinch, K.,Mee, S.P.,Evans, G.B.,Tyler, P.C.,Furneaux, R.H.,Almo, S.C.,Schramm, V.L. L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase J.Am.Chem.Soc., 130:842-844, 2008 Cited by PubMed: 18154341 DOI: 10.1021/ja710733g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.099 Å)

Structure validation