PDB: 435 件ウェブページステータス検索Chemie searchBIRD

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2LGB	Modified A22Gly-B31Arg Human Insulin 分子名称: Insulin A chain, Insulin B chain 著者 Bocian, W, Kozerski, L. 登録日 2011-07-25 公開日 2012-04-11 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Recombinant A22(G)-B31 (R)-human insulin. A22 addition introduces conformational mobility in B chain C-terminus. J.Biomol.Nmr, 52, 2012
2L1Z	NMR Structure of human insulin mutant GLY-B20-D-ALA, GLY-B23-D-ALA PRO-B28-LYS, LYS-B29-PRO, 20 Structures 分子名称: Insulin A chain, Insulin B chain 著者 Wan, Z.L, Hua, Q.X, Huang, K, Hu, S.Q, Philips, N.B, Katsoyannis, J.W, Weiss, M.A. 登録日 2010-08-09 公開日 2011-08-31 最終更新日 2020-02-05 実験手法 SOLUTION NMR 主引用文献 Chiral Protein Engineering and its Application in G Health To be Published
2M2P	Structure of [D-HisB24] insulin analogue at pH 8.0 分子名称: Insulin A chain, Insulin B chain 著者 Zakova, L, Veverka, V, Jiracek, J. 登録日 2012-12-29 公開日 2013-03-06 最終更新日 2013-06-05 実験手法 SOLUTION NMR 主引用文献 Structural integrity of the B24 site in human insulin is important for hormone functionality. J.Biol.Chem., 288, 2013
2L1Y	NMR Structure of human insulin mutant GLY-B20-D-ALA, GLY-B23-D-ALA PRO-B28-LYS, LYS-B29-PRO, 20 Structures 分子名称: Insulin A chain, Insulin B chain 著者 Wan, Z.L, Hua, Q.X, Huang, K, Hu, S.Q, Philips, N.B, Katsoyannis, J.W, Weiss, M.A. 登録日 2010-08-09 公開日 2011-08-31 実験手法 SOLUTION NMR 主引用文献 Chiral Protein Engineering and its Application in G Health To be Published
2N2W	Solution structure of [B26-B29 triazole cross-linked]-insulin analogue at pH 8.0 分子名称: Insulin A chain, Insulin B chain 著者 Veverka, V, Hexnerova, R, Jiracek, J. 登録日 2015-05-15 公開日 2016-02-03 実験手法 SOLUTION NMR 主引用文献 Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016
2MPI	Solution structure of B24G insulin 分子名称: insulin chain A, insulin chain B 著者 Yang, Y, Wickramasinghe, N.P, Hua, Q, Weiss, M.A. 登録日 2014-05-19 公開日 2014-12-24 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Protective hinge in insulin opens to enable its receptor engagement. Proc.Natl.Acad.Sci.USA, 111, 2014
2MPG	Solution structure of the [AibB8,LysB28,ProB29]-insulin analogue 分子名称: Insulin A chain, Insulin B chain 著者 Kosinova, L, Jiracek, J, Zakova, L, Veverka, V. 登録日 2014-05-17 公開日 2014-06-11 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Insight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin. Biochemistry, 53, 2014
2MLI	NMR structure of B25-(alpha, beta)-dehydro-phenylalanine insulin 分子名称: Insulin 著者 Yang, Y, Weiss, M. 登録日 2014-02-27 公開日 2014-08-20 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Protective hinge in insulin opens to enable its receptor engagement. Proc.Natl.Acad.Sci.USA, 111, 2014
2M1D	Biosynthetic engineered B28K-B29P human insulin monomer structure in in water/acetonitrile solutions. 分子名称: Insulin 著者 Bocian, W, Kozerski, L. 登録日 2012-11-26 公開日 2013-02-27 最終更新日 2013-05-22 実験手法 SOLUTION NMR 主引用文献 Biosynthetic engineered B28(K)-B29(P) human insulin monomer structure in water and in water/acetonitrile solutions. J.Biomol.Nmr, 55, 2013
2KJU	NMR structure of human insulin mutant glu-b21-d-glu, his-b10 asp pro-b28-lys, lys-b29-pro, 20 structures 分子名称: Insulin 著者 Hua, Q.X, Huang, K, Hu, S.Q, Katsoyanni, P, Weiss, M.A. 登録日 2009-06-10 公開日 2010-06-16 最終更新日 2021-10-13 実験手法 SOLUTION NMR 主引用文献 Acceleration of Protein Fibrillation by Chiral Destabilization of Beta-Turn To be Published
2KQP	NMR Structure of Proinsulin 分子名称: Insulin 著者 Yang, Y, Hua, Q.X, Mackin, R.B, Weiss, M.A. 登録日 2009-11-12 公開日 2010-01-26 最終更新日 2021-10-13 実験手法 SOLUTION NMR 主引用文献 Solution structure of proinsulin: connecting domain flexibility and prohormone processing. J.Biol.Chem., 285, 2010
2KXK	Human Insulin Mutant A22Gly-B31Lys-B32Arg 分子名称: Insulin A chain, Insulin B chain 著者 Bocian, W, Kozerski, L. 登録日 2010-05-07 公開日 2011-06-01 最終更新日 2011-07-13 実験手法 SOLUTION NMR 主引用文献 Novel recombinant insulin analogue with flexible C - terminus in B chain. NMR structure of biosynthetic engineered A22G-B31K-B32R human insulin monomer in water /acetonitrile solution. To be Published
5KQV	Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, Insulin receptor,Insulin receptor, ... 著者 Lawrence, M.C, Smith, B.J, Croll, T.I. 登録日 2016-07-06 公開日 2017-07-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.4 Å) 主引用文献 How insulin engages its primary binding site on the insulin receptor. Nature, 493, 2013
4OGA	Insulin in complex with Site 1 of the human insulin receptor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... 著者 Lawrence, M.C, Menting, J.G. 登録日 2014-01-15 公開日 2014-08-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Protective hinge in insulin opens to enable its receptor engagement. Proc.Natl.Acad.Sci.USA, 111, 2014
8CLS	Drosophila melanogaster insulin receptor ectodomain in complex with DILP5 分子名称: Insulin-like receptor, Probable insulin-like peptide 5, Probable insulin-like peptide 5 A chain 著者 Viola, C.M, Brzozowski, A.M, Shafi, T. 登録日 2023-02-17 公開日 2023-12-20 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans. Nat Commun, 14, 2023
4XSS	Insulin-like growth factor I in complex with site 1 of a hybrid insulin receptor / Type 1 insulin-like growth factor receptor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ... 著者 Lawrence, C, Kong, G.K.-W, Menting, J.G, Lawrence, M.C. 登録日 2015-01-22 公開日 2015-06-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors. Structure, 23, 2015
7KD6	Insulin Receptor L1-CR plus alphaCT fragment in co-complex with Fv 83-7 and single-chain insulin SCI-b 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Lawrence, M.C, Menting, J.G. 登録日 2020-10-08 公開日 2021-10-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Single-chain insulin analogs threaded by the insulin receptor alpha CT domain. Biophys.J., 2022
6FF3	Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human IGF-I 分子名称: Insulin-like growth factor I, Neural/ectodermal development factor IMP-L2 著者 Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D, Viola, C.M. 登録日 2018-01-03 公開日 2018-09-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Nat Commun, 9, 2018
6FEY	Crystal structure of Drosophila neural ectodermal development factor Imp-L2 with Drosophila DILP5 insulin 分子名称: Neural/ectodermal development factor IMP-L2, Probable insulin-like peptide 5 著者 Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D. 登録日 2018-01-03 公開日 2018-09-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.48 Å) 主引用文献 Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Nat Commun, 9, 2018
7WRQ	Structure of Human IGF1/IGFBP3/ALS Ternary Complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor-binding protein 3, Insulin-like growth factor-binding protein complex acid labile subunit, ... 著者 Kim, H, Fu, Y, Kim, H.M. 登録日 2022-01-27 公開日 2022-08-10 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex Nat Commun, 13, 2022
3E4Z	Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II 分子名称: Insulin-degrading enzyme, Insulin-like growth factor II, ZINC ION 著者 Guo, Q, Manolopoulou, M, Tang, W.-J. 登録日 2008-08-12 公開日 2009-08-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme. J.Mol.Biol., 395, 2010
6BFC	Cryo-EM structure of human insulin degrading enzyme in complex with insulin 分子名称: Insulin, Insulin-degrading enzyme 著者 Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. 登録日 2017-10-26 公開日 2017-12-27 最終更新日 2021-04-28 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
6B3Q	Cryo-EM structure of human insulin degrading enzyme in complex with insulin 分子名称: Insulin, Insulin-degrading enzyme 著者 Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. 登録日 2017-09-22 公開日 2017-11-22 最終更新日 2021-04-28 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
6VEP	Human insulin in complex with the human insulin microreceptor in turn in complex with Fv 83-7 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Lawrence, M.C, Menting, J.G.T. 登録日 2020-01-02 公開日 2020-06-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 A structurally minimized yet fully active insulin based on cone-snail venom insulin principles. Nat.Struct.Mol.Biol., 27, 2020
6B70	Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain and insulin 分子名称: FAB H11-E heavy chain, FAB H11-E light chain, Insulin, ... 著者 Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. 登録日 2017-10-03 公開日 2017-12-27 最終更新日 2021-04-28 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018

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