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6B70

Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain and insulin

Summary for 6B70
Entry DOI10.2210/pdb6b70/pdb
Related6B3Q 6B7Y 6B7Z
EMDB information7041 7062 7065 7066
DescriptorInsulin-degrading enzyme, FAB H11-E heavy chain, FAB H11-E light chain, ... (4 entities in total)
Functional Keywordside, insulin degrading enzyme, amyloid beta, biosynthetic protein, hydrolase-immune system-hormone complex, hydrolase/immune system/hormone
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains8
Total formula weight340003.41
Authors
Liang, W.G.,Zhang, Z.,Bailey, L.J.,Kossiakoff, A.A.,Tan, Y.Z.,Wei, H.,Carragher, B.,Potter, S.C.,Tang, W.J. (deposition date: 2017-10-03, release date: 2017-12-27, Last modification date: 2021-04-28)
Primary citationZhang, Z.,Liang, W.G.,Bailey, L.J.,Tan, Y.Z.,Wei, H.,Wang, A.,Farcasanu, M.,Woods, V.A.,McCord, L.A.,Lee, D.,Shang, W.,Deprez-Poulain, R.,Deprez, B.,Liu, D.R.,Koide, A.,Koide, S.,Kossiakoff, A.A.,Li, S.,Carragher, B.,Potter, C.S.,Tang, W.J.
Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7:-, 2018
Cited by
PubMed: 29596046
DOI: 10.7554/eLife.33572
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.7 Å)
Structure validation

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