2MPG

Solution structure of the [AibB8,LysB28,ProB29]-insulin analogue

Summary for 2MPG

DescriptorInsulin A chain, Insulin B chain (2 entities in total)
Functional Keywordsinsulin analogue, hormone
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5845.7
Authors
Kosinova, L.,Jiracek, J.,Zakova, L.,Veverka, V. (deposition date: 2014-05-17, release date: 2014-06-11, Last modification date: 2015-02-18)
Primary citation
Kosinova, L.,Veverka, V.,Novotna, P.,Collinsova, M.,Urbanova, M.,Moody, N.R.,Turkenburg, J.P.,Jiracek, J.,Brzozowski, A.M.,Zakova, L.
Insight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin.
Biochemistry, 53:3392-3402, 2014
PubMed: 24819248 (PDB entries with the same primary citation)
DOI: 10.1021/bi500073z
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers00.3%8.7%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures