7XBX
| Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and Gi1 | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q. | Deposit date: | 2022-03-22 | Release date: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Activation of the human chemokine receptor CX3CR1 regulated by cholesterol. Sci Adv, 8, 2022
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7WXW
| GPR110/Gs complex | Descriptor: | Adhesion G-protein coupled receptor F1, Engineered mini Galpha-s subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | He, Y, Zhu, X. | Deposit date: | 2022-02-15 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling. Nat Commun, 13, 2022
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7X2V
| GPR110/Gi complex | Descriptor: | Adhesion G-protein coupled receptor F1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | He, Y, Zhu, X. | Deposit date: | 2022-02-26 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling. Nat Commun, 13, 2022
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7XKF
| Cryo-EM structure of DHEA-ADGRG2-BT-Gs complex at lower state | Descriptor: | 3-BETA-HYDROXY-5-ANDROSTEN-17-ONE, Adhesion G-protein coupled receptor G2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Guo, S.C, Xiao, P, Lin, H, Sun, J.P, Yu, X. | Deposit date: | 2022-04-19 | Release date: | 2022-08-10 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structures of the ADGRG2-G s complex in apo and ligand-bound forms. Nat.Chem.Biol., 18, 2022
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7XKD
| Cryo-EM structure of DHEA-ADGRG2-BT-Gs complex | Descriptor: | 3-BETA-HYDROXY-5-ANDROSTEN-17-ONE, Adhesion G-protein coupled receptor G2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Guo, S.C, Xiao, P, Lin, H, Sun, J.P, Yu, X. | Deposit date: | 2022-04-19 | Release date: | 2022-08-10 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structures of the ADGRG2-G s complex in apo and ligand-bound forms. Nat.Chem.Biol., 18, 2022
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7X10
| ADGRL3/miniG12 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Isoform 3 of Adhesion G protein-coupled receptor L3, ... | Authors: | He, Y, Qian, Y. | Deposit date: | 2022-02-22 | Release date: | 2022-11-09 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling. Mol.Cell, 82, 2022
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7WU9
| Cryo-EM structure of the human EP3-Gi signaling complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Suno, R, Sugita, Y, Morimoto, K, Iwasaki, K, Kato, T, Kobayashi, T. | Deposit date: | 2022-02-07 | Release date: | 2022-08-17 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.375 Å) | Cite: | Structural insights into the G protein selectivity revealed by the human EP3-G i signaling complex. Cell Rep, 40, 2022
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7XK2
| Cryo-EM Structure of Human Niacin Receptor HCA2-Gi protein complex | Descriptor: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yang, Y, Kang, H.J, Gao, R.G, Wang, J.J, Han, G.W, DiBerto, J.F, Wu, L.J, Tong, J.H, Qu, L, Wu, Y.R, Pileski, R, Li, X.M, Zhang, X.C, Zhao, S.W, Kenakin, T, Wang, Q, Stevens, R.C, Peng, W, Roth, B.L, Rao, Z.H, Liu, Z.J. | Deposit date: | 2022-04-19 | Release date: | 2023-02-22 | Last modified: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into the human niacin receptor HCA2-G i signalling complex. Nat Commun, 14, 2023
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7XK8
| Cryo-EM structure of the Neuromedin U receptor 2 (NMUR2) in complex with G Protein and its endogeneous Peptide-Agonist NMU25 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Zhao, W, Wenru, Z, Mu, W, Minmin, L, Shutian, C, Tingting, T, Gisela, S, Holger, W, Albert, B, Cuiying, Y, Xiaojing, C, Han, S, Wu, B, Zhao, Q. | Deposit date: | 2022-04-19 | Release date: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Ligand recognition and activation of neuromedin U receptor 2. Nat Commun, 13, 2022
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7XJJ
| Cryo-EM structure of the galanin-bound GALR1-miniGo complex | Descriptor: | G protein subunit alpha o1,Guanine nucleotide-binding protein G(o) subunit alpha, Galanin, Galanin receptor type 1, ... | Authors: | Jiang, W, Zheng, S. | Deposit date: | 2022-04-18 | Release date: | 2023-05-03 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural insights into galanin receptor signaling. Proc.Natl.Acad.Sci.USA, 119, 2022
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7Y36
| Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, HYDROXIDE ION, ... | Authors: | Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z. | Deposit date: | 2022-06-10 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex to be published
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7Y35
| Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex | Descriptor: | Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z. | Deposit date: | 2022-06-09 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex To Be Published
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7XZ5
| GPR119-Gs-LPC complex | Descriptor: | (4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, P, Huang, S, Jiang, Y, Xu, H.E. | Deposit date: | 2022-06-02 | Release date: | 2022-08-24 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nat.Struct.Mol.Biol., 29, 2022
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7XZ6
| GPR119-Gs-APD668 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Xu, P, Huang, S, Jiang, Y, Xu, H.E. | Deposit date: | 2022-06-02 | Release date: | 2022-08-24 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nat.Struct.Mol.Biol., 29, 2022
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7XW5
| TSHR-thyroid stimulating hormone-Gs-ML109 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, Glycoprotein hormones alpha chain, ... | Authors: | Duan, J, Xu, P, Luan, X, Ji, Y, Yuan, Q, He, X, Ye, J, Cheng, X, Jiang, H, Zhang, S, Jiang, Y, Xu, H.E. | Deposit date: | 2022-05-26 | Release date: | 2022-08-24 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature, 609, 2022
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7XTQ
| Cryo-EM structure of the R399-bound GPBAR-Gs complex | Descriptor: | G-protein coupled bile acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Ma, L, Yang, F, Wu, X, Mao, C, Sun, J, Yu, X, Zhang, Y, Zhang, P. | Deposit date: | 2022-05-17 | Release date: | 2022-07-06 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity. Proc.Natl.Acad.Sci.USA, 119, 2022
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7Y24
| Cryo-EM structure of the octreotide-bound SSTR2-miniGo-scFv16 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... | Authors: | Chen, S, Zheng, S. | Deposit date: | 2022-06-09 | Release date: | 2022-10-19 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Molecular basis for the selective G protein signaling of somatostatin receptors. Nat.Chem.Biol., 19, 2023
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7Y27
| Cryo-EM structure of the SST-14-bound SSTR2-miniGq-scFv16 complex | Descriptor: | CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Chen, S, Zheng, S. | Deposit date: | 2022-06-09 | Release date: | 2022-10-19 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Molecular basis for the selective G protein signaling of somatostatin receptors. Nat.Chem.Biol., 19, 2023
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7Y26
| Cryo-EM structure of the octreotide-bound SSTR2-miniGq-scFv16 complex | Descriptor: | Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Chen, S, Zheng, S. | Deposit date: | 2022-06-09 | Release date: | 2022-10-19 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Molecular basis for the selective G protein signaling of somatostatin receptors. Nat.Chem.Biol., 19, 2023
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7Y12
| Cryo-EM structure of MrgD-Gi complex with beta-alanine | Descriptor: | BETA-ALANINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | Deposit date: | 2022-06-06 | Release date: | 2022-07-20 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
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7Y15
| Cryo-EM structure of apo-state MrgD-Gi complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | Deposit date: | 2022-06-06 | Release date: | 2022-07-20 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
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7Y89
| Structure of the GPR17-Gi complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Ye, F, Chen, G. | Deposit date: | 2022-06-23 | Release date: | 2022-10-12 | Last modified: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Cryo-EM structure of G-protein-coupled receptor GPR17 in complex with inhibitory G protein. MedComm (2020), 3, 2022
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7XTB
| Serotonin 6 (5-HT6) receptor-Gs-Nb35 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. | Deposit date: | 2022-05-16 | Release date: | 2022-07-27 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
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7XTA
| Serotonin 4 (5-HT4) receptor-Gi-scFv16 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. | Deposit date: | 2022-05-16 | Release date: | 2022-07-27 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
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7XTC
| Serotonin 7 (5-HT7) receptor-Gs-Nb35 complex | Descriptor: | 3-(2-azanylethyl)-1H-indole-5-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. | Deposit date: | 2022-05-16 | Release date: | 2022-07-27 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
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