7WU9

Cryo-EM structure of the human EP3-Gi signaling complex

Summary for 7WU9

Entry DOI	10.2210/pdb7wu9/pdb
EMDB information	32824
Descriptor	Prostaglandin E2 receptor EP3 subtype, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (5 entities in total)
Functional Keywords	gpcr, signal transduction, membrane protein, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	149511.54
Authors	Suno, R.,Sugita, Y.,Morimoto, K.,Iwasaki, K.,Kato, T.,Kobayashi, T. (deposition date: 2022-02-07, release date: 2022-08-17, Last modification date: 2023-10-04)
Primary citation	Suno, R.,Sugita, Y.,Morimoto, K.,Takazaki, H.,Tsujimoto, H.,Hirose, M.,Suno-Ikeda, C.,Nomura, N.,Hino, T.,Inoue, A.,Iwasaki, K.,Kato, T.,Iwata, S.,Kobayashi, T. Structural insights into the G protein selectivity revealed by the human EP3-G i signaling complex. Cell Rep, 40:111323-111323, 2022 Cited by PubMed: 36103815 DOI: 10.1016/j.celrep.2022.111323 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.375 Å)

Structure validation