7XTC
Serotonin 7 (5-HT7) receptor-Gs-Nb35 complex
Summary for 7XTC
Entry DOI | 10.2210/pdb7xtc/pdb |
EMDB information | 33446 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total) |
Functional Keywords | gpcr, serotonin receptor, 5-ht, 5-ht7 receptor, signaling complex, cryo-em structure, ligand selectivity, g protein selectivity, structure-function relationships, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 171771.18 |
Authors | Huang, S.,Xu, P.,Shen, D.D.,Simon, I.A.,Mao, C.,Tan, Y.,Zhang, H.,Harpsoe, K.,Li, H.,Zhang, Y.,You, C.,Yu, X.,Jiang, Y.,Zhang, Y.,Gloriam, D.E.,Xu, H.E. (deposition date: 2022-05-16, release date: 2022-07-27, Last modification date: 2022-08-03) |
Primary citation | Huang, S.,Xu, P.,Shen, D.D.,Simon, I.A.,Mao, C.,Tan, Y.,Zhang, H.,Harpsoe, K.,Li, H.,Zhang, Y.,You, C.,Yu, X.,Jiang, Y.,Zhang, Y.,Gloriam, D.E.,Xu, H.E. GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82:2681-2695.e6, 2022 Cited by PubMed: 35714614DOI: 10.1016/j.molcel.2022.05.031 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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