7XTA

Serotonin 4 (5-HT4) receptor-Gi-scFv16 complex

Summary for 7XTA

Entry DOI	10.2210/pdb7xta/pdb
EMDB information	33444
Descriptor	Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, scFv16, ... (6 entities in total)
Functional Keywords	gpcr, serotonin receptor, 5-ht, 5-ht4 receptor, signaling complex, cryo-em structure, ligand selectivity, g protein selectivity, structure-function relationships, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	172490.13
Authors	Huang, S.,Xu, P.,Shen, D.D.,Simon, I.A.,Mao, C.,Tan, Y.,Zhang, H.,Harpsoe, K.,Li, H.,Zhang, Y.,You, C.,Yu, X.,Jiang, Y.,Zhang, Y.,Gloriam, D.E.,Xu, H.E. (deposition date: 2022-05-16, release date: 2022-07-27, Last modification date: 2022-08-03)
Primary citation	Huang, S.,Xu, P.,Shen, D.D.,Simon, I.A.,Mao, C.,Tan, Y.,Zhang, H.,Harpsoe, K.,Li, H.,Zhang, Y.,You, C.,Yu, X.,Jiang, Y.,Zhang, Y.,Gloriam, D.E.,Xu, H.E. GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82:2681-2695.e6, 2022 Cited by PubMed: 35714614 DOI: 10.1016/j.molcel.2022.05.031 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation