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PDB: 376 results

6CRK
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BU of 6crk by Molmil
Heterotrimeric G-protein in complex with an antibody fragment
Descriptor: CITRATE ANION, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Maeda, S, Dawson, R, Kobilka, B.
Deposit date:2018-03-19
Release date:2018-10-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Development of an antibody fragment that stabilizes GPCR/G-protein complexes.
Nat Commun, 9, 2018
3UMR
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BU of 3umr by Molmil
Crystal structure of the G202D mutant of human G-alpha-i1
Descriptor: CHLORIDE ION, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Johnston, C.A, Afshar, K, Snyder, J.T, Tall, G.G, Gonczy, P, Siderovski, D.P, Willard, F.S.
Deposit date:2011-11-14
Release date:2012-10-24
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Determinants Underlying the Temperature-sensitive Nature of a G-alpha Mutant in Asymmetric Cell Division of Caenorhabditis elegans
To be Published
2OM2
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BU of 2om2 by Molmil
Crystal Structure Of Human G[alpha]i1 Bound To The Goloco Motif Of Rgs14
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ...
Authors:Siderovski, D.P, Kimple, R.J.
Deposit date:2007-01-20
Release date:2007-07-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-based Protocol for Identifying Mutations that Enhance Protein-Protein Binding Affinities.
J.Mol.Biol., 371, 2007
3UMS
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BU of 3ums by Molmil
Crystal structure of the G202A mutant of human G-alpha-i1
Descriptor: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Lambert, N.A, Johnston, C.A, Cappell, S.D, Kuravi, S, Kimple, A.J, Willard, F.S, Siderovski, D.P.
Deposit date:2011-11-14
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.343 Å)
Cite:Correction for Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity
Proc.Natl.Acad.Sci.USA, 2012
3ONW
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BU of 3onw by Molmil
Structure of a G-alpha-i1 mutant with enhanced affinity for the RGS14 GoLoco motif.
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, ...
Authors:Bosch, D, Kimple, A.J, Sammond, D.W, Miley, M.J, Machius, M, Kuhlman, B, Willard, F.S, Siderovski, D.P.
Deposit date:2010-08-30
Release date:2010-11-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein {alpha} Subunit Mutants.
J.Biol.Chem., 286, 2011
8PJK
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BU of 8pjk by Molmil
ST171-bound serotonin 5-HT1A receptor - Gi Protein Complex
Descriptor: (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 5-hydroxytryptamine receptor 1A, 6-[3-[2-(2-methoxyphenoxy)ethylamino]propoxy]-4~{H}-1,4-benzoxazin-3-one, ...
Authors:Schneider, J, Gmeiner, P, Rasmussen, T, Boettcher, B.
Deposit date:2023-06-23
Release date:2024-05-29
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Discovery of a functionally selective serotonin 1A receptor agonist for the treatment of pain
To Be Published
7TRP
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BU of 7trp by Molmil
Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator LY2033298
Descriptor: 3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment scFv16, ...
Authors:Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M.
Deposit date:2022-01-30
Release date:2023-05-17
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor
Elife, 2023
7EJX
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BU of 7ejx by Molmil
Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand
Descriptor: (1R,2R)-N-[(2S,3S)-2-azanyl-3-methyl-pentyl]-N-[4-(4-propylphenyl)phenyl]-2-pyridin-2-yl-cyclopropane-1-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Xu, J, Chen, G, Liu, Z, Du, Y.
Deposit date:2021-04-02
Release date:2022-04-13
Last modified:2022-10-26
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex.
Nat Commun, 13, 2022
7MBY
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BU of 7mby by Molmil
Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex
Descriptor: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ...
Authors:Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M.
Deposit date:2021-04-01
Release date:2021-05-26
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (2.44 Å)
Cite:Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.
Plos Biol., 19, 2021
8JIS
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BU of 8jis by Molmil
Cryo-EM structure of the GLP-1R/GCGR dual agonist peptide15-bound human GLP-1R-Gs complex
Descriptor: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Yang, L, Zhou, Q.T, Dai, A.T, Zhao, F.H, Chang, R.L, Ying, T.L, Wu, B.L, Yang, D.H, Wang, M.W, Cong, Z.T.
Deposit date:2023-05-27
Release date:2023-11-08
Method:ELECTRON MICROSCOPY (2.46 Å)
Cite:Structural analysis of the dual agonism at GLP-1R and GCGR.
Proc.Natl.Acad.Sci.USA, 120, 2023
8YKV
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BU of 8ykv by Molmil
Cryo-EM structure of succinate receptor SUCR1 bound to compound 31
Descriptor: (2~{S})-2-[[6-[4-(trifluoromethyloxy)phenyl]pyridin-2-yl]carbonylamino]butanedioic acid, Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Li, C, Liu, H, Li, J, Zhu, H, Fu, W, Xu, H.E.
Deposit date:2024-03-05
Release date:2024-05-29
Method:ELECTRON MICROSCOPY (2.48 Å)
Cite:Cryo-EM structure of succinate receptor SUCR1 bound to compound 31
To Be Published
7T2G
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BU of 7t2g by Molmil
CryoEM structure of mu-opioid receptor - Gi protein complex bound to mitragynine pseudoindoxyl (MP)
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Seven, A.B, Qu, Q, Robertson, M.J, Wang, H, Kobilka, B.K, Skiniotis, G.
Deposit date:2021-12-04
Release date:2022-12-07
Last modified:2023-02-15
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Insights into distinct signaling profiles of the mu OR activated by diverse agonists.
Nat.Chem.Biol., 2022
7TRQ
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BU of 7trq by Molmil
Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator VU0467154
Descriptor: 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, 5-amino-3,4-dimethyl-N-{[4-(trifluoromethanesulfonyl)phenyl]methyl}thieno[2,3-c]pyridazine-6-carboxamide, Antibody fragment scFv16, ...
Authors:Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M.
Deposit date:2022-01-30
Release date:2023-05-17
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor
Elife, 2023
1Y3A
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BU of 1y3a by Molmil
Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ...
Authors:Johnston, C.A, Willard, F.S, Jezyk, M.R, Fredericks, Z, Bodor, E.T, Jones, M.B, Blaesius, R, Harden, T.K, Sondek, J, Watts, V.J, Ramer, J.K, Siderovski, D.P.
Deposit date:2004-11-24
Release date:2005-07-12
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
Structure, 7, 2005
8FEG
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BU of 8feg by Molmil
CryoEM structure of Kappa Opioid Receptor bound to a semi-peptide and Gi1
Descriptor: ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Fay, J.F, Che, T.
Deposit date:2022-12-06
Release date:2023-12-06
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (2.54 Å)
Cite:Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor.
Nat Commun, 14, 2023
7S8M
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BU of 7s8m by Molmil
CryoEM structure of Gi-coupled MRGPRX2 with peptide agonist Cortistatin-14
Descriptor: Cortistatin 14, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L.
Deposit date:2021-09-18
Release date:2021-11-17
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (2.54 Å)
Cite:Structure, function and pharmacology of human itch GPCRs.
Nature, 600, 2021
8J6P
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BU of 8j6p by Molmil
Cryo-EM structure of the MK-6892-bound human HCAR2-Gi1 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide, CHOLESTEROL, ...
Authors:Mao, C, Gao, M, Zang, S, Zhu, Y, Ma, X, Zhang, Y.
Deposit date:2023-04-26
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Orthosteric and allosteric modulation of human HCAR2 signaling complex.
Nat Commun, 14, 2023
2GTP
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BU of 2gtp by Molmil
Crystal structure of the heterodimeric complex of human RGS1 and activated Gi alpha 1
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ...
Authors:Soundararajan, M, Turnbull, A.P, Ugochukwu, E, Gorrec, F, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Doyle, D.A, Structural Genomics Consortium (SGC)
Deposit date:2006-04-28
Release date:2006-05-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
8JR9
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BU of 8jr9 by Molmil
Small molecule agonist (PCO371) bound to human parathyroid hormone receptor type 1 (PTH1R)
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha-1, ...
Authors:Zhao, L, He, Q, Yuan, Q, Gu, Y, He, X, Shan, H, Li, J, Wang, K, Li, Y, Hu, W, Wu, K, Shen, J, Xu, H.E.
Deposit date:2023-06-16
Release date:2023-08-02
Last modified:2023-10-04
Method:ELECTRON MICROSCOPY (2.57 Å)
Cite:Conserved class B GPCR activation by a biased intracellular agonist.
Nature, 621, 2023
8JIR
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BU of 8jir by Molmil
Cryo-EM structure of the GLP-1R/GCGR dual agonist SAR425899-bound human GLP-1R-Gs complex
Descriptor: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Yang, L, Zhou, Q.T, Dai, A.T, Zhao, F.H, Chang, R.L, Ying, T.L, Wu, B.L, Yang, D.H, Wang, M.W, Cong, Z.T.
Deposit date:2023-05-27
Release date:2023-09-06
Method:ELECTRON MICROSCOPY (2.57 Å)
Cite:Structural analysis of the dual agonism at GLP-1R and GCGR.
Proc.Natl.Acad.Sci.USA, 120, 2023
7S8O
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BU of 7s8o by Molmil
CryoEM structure of Gi-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573
Descriptor: (3R)-N,N-dimethyl-1-[(8S)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L.
Deposit date:2021-09-18
Release date:2021-11-17
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (2.58 Å)
Cite:Structure, function and pharmacology of human itch GPCRs.
Nature, 600, 2021
8IOD
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BU of 8iod by Molmil
Cryo-EM structure of the PG-901-bound human melanocortin receptor 5 (MC5R)-Gs complex
Descriptor: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,HiBiT, ...
Authors:Feng, W.B, Zhou, Q.T, Chen, X.Y, Dai, A.T, Cai, X.Q, Liu, X, Zhao, F.H, Chen, Y, Ye, C.Y, Xu, Y.N, Cong, Z.T, Li, H, Lin, S, Yang, D.H, Wang, M.W.
Deposit date:2023-03-10
Release date:2023-09-20
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.59 Å)
Cite:Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors.
Cell Discov, 9, 2023
9BKJ
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BU of 9bkj by Molmil
Cholecystokinin 1 receptor (CCK1R) Y140A mutant, Gq chimera (mGsqi) complex
Descriptor: AMINO GROUP, Cholecystokinin receptor type A, Cholecystokinin-8, ...
Authors:Cary, B.P, Harikumar, K.G, Zhao, P, Desai, A.J, Mobbs, J.M, Toufaily, C, Furness, S.G.B, Christopoulos, A, Belousoff, M.J, Wootten, D, Sexton, P.M, Miller, L.J.
Deposit date:2024-04-29
Release date:2024-05-22
Method:ELECTRON MICROSCOPY (2.59 Å)
Cite:Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling
To Be Published
8XZH
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BU of 8xzh by Molmil
Cryo-EM structure of the MM07-bound human APLNR-Gi complex
Descriptor: Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Wang, W, Ji, S, Zhang, Y.
Deposit date:2024-01-21
Release date:2024-03-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structure-based design of non-hypertrophic apelin receptor modulator.
Cell, 187, 2024
8JZ7
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BU of 8jz7 by Molmil
Cryo-EM structure of MK-6892-bound HCAR2 in complex with Gi protein
Descriptor: 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H.
Deposit date:2023-07-04
Release date:2023-10-04
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2.
Signal Transduct Target Ther, 8, 2023

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