7T2G

CryoEM structure of mu-opioid receptor - Gi protein complex bound to mitragynine pseudoindoxyl (MP)

Summary for 7T2G

• Entry DOI: 10.2210/pdb7t2g/pdb
• EMDB information: 25612
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: gpcr, mu-opioid receptor, lofentanil (lft), mitragynine pseudoindoxyl (mp), membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 142258.90

Authors

Seven, A.B.,Qu, Q.,Robertson, M.J.,Wang, H.,Kobilka, B.K.,Skiniotis, G. (deposition date: 2021-12-04, release date: 2022-12-07, Last modification date: 2023-02-15)

• Primary citation: Qu, Q.,Huang, W.,Aydin, D.,Paggi, J.M.,Seven, A.B.,Wang, H.,Chakraborty, S.,Che, T.,DiBerto, J.F.,Robertson, M.J.,Inoue, A.,Suomivuori, C.M.,Roth, B.L.,Majumdar, S.,Dror, R.O.,Kobilka, B.K.,Skiniotis, G.; Insights into distinct signaling profiles of the mu OR activated by diverse agonists.; Nat.Chem.Biol., 2022; PubMed: 36411392; DOI: 10.1038/s41589-022-01208-y

Experimental method

ELECTRON MICROSCOPY (2.5 Å)