3UMS

Crystal structure of the G202A mutant of human G-alpha-i1

Replaces:  2PZ2

Summary for 3UMS

DescriptorGuanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ... (5 entities in total)
Functional Keywordsgtpase, g-protein, hydrolysis, hydrolase, cell cycle
Biological sourceHomo sapiens (human)
Cellular locationNucleus (By similarity) P63096
Total number of polymer chains1
Total molecular weight41003.78
Authors
Lambert, N.A.,Johnston, C.A.,Cappell, S.D.,Kuravi, S.,Kimple, A.J.,Willard, F.S.,Siderovski, D.P. (deposition date: 2011-11-14, release date: 2012-02-08)
Primary citation
Lambert, N.A.,Johnston, C.A.,Cappell, S.D.,Kuravi, S.,Kimple, A.J.,Willard, F.S.,Siderovski, D.P.
Correction for Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity
Proc.Natl.Acad.Sci.USA, 2012
DOI: 10.1073/pnas.1200427109
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.343 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.224400.7%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3ums
no rotation
Molmil generated image of 3ums
rotated about x axis by 90°
Molmil generated image of 3ums
rotated about y axis by 90°