8J6Q
Cryo-EM structure of the 3-HB and compound 9n-bound human HCAR2-Gi1 complex
Summary for 8J6Q
Entry DOI | 10.2210/pdb8j6q/pdb |
EMDB information | 36011 |
Descriptor | Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (10 entities in total) |
Functional Keywords | hydroxycarboxylic acid receptor, 3-hb, class a gpcr, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 146390.70 |
Authors | |
Primary citation | Mao, C.,Gao, M.,Zang, S.K.,Zhu, Y.,Shen, D.D.,Chen, L.N.,Yang, L.,Wang, Z.,Zhang, H.,Wang, W.W.,Shen, Q.,Lu, Y.,Ma, X.,Zhang, Y. Orthosteric and allosteric modulation of human HCAR2 signaling complex. Nat Commun, 14:7620-7620, 2023 Cited by PubMed: 37993467DOI: 10.1038/s41467-023-43537-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.6 Å) |
Structure validation
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