8J6Q

Cryo-EM structure of the 3-HB and compound 9n-bound human HCAR2-Gi1 complex

Summary for 8J6Q

• Entry DOI: 10.2210/pdb8j6q/pdb
• EMDB information: 36011
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (10 entities in total)
• Functional Keywords: hydroxycarboxylic acid receptor, 3-hb, class a gpcr, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 146390.70

Authors

Mao, C.,Gao, M.,Zang, S.,Zhu, Y.,Ma, X.,Zhang, Y. (deposition date: 2023-04-26, release date: 2023-12-06)

• Primary citation: Mao, C.,Gao, M.,Zang, S.K.,Zhu, Y.,Shen, D.D.,Chen, L.N.,Yang, L.,Wang, Z.,Zhang, H.,Wang, W.W.,Shen, Q.,Lu, Y.,Ma, X.,Zhang, Y.; Orthosteric and allosteric modulation of human HCAR2 signaling complex.; Nat Commun, 14:7620-7620, 2023; PubMed: 37993467; DOI: 10.1038/s41467-023-43537-z

Experimental method

ELECTRON MICROSCOPY (2.6 Å)