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8J6Q

Cryo-EM structure of the 3-HB and compound 9n-bound human HCAR2-Gi1 complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-1polymer35240225.81UniProt (P63096)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer33937285.71UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)
3C
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer586375.31UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
4D
(S)		single Fab chain (scFv16)polymer25026610.61synthetic construct
5E
(R)		Hydroxycarboxylic acid receptor 2polymer29534366.11UniProt (Q8TDS4)
Pfam (PF00001)		Homo sapiens (human)G-protein coupled receptor 109A,G-protein coupled receptor HM74A,Niacin receptor 1,Nicotinic acid receptor
6F
(R)		7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamidenon-polymer428.51Chemie (IX8)
PubChem (25101223)
PubChem (44579762)
PubChem (44579763)
7G, I
(R)		CHOLESTEROLnon-polymer386.72Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (45044259)
PubChem (49853509)
PubChem (50990013)
PubChem (176980071)
PubChem (18640088)
PubChem (52934537)
PubChem (1715243)
PubChem (1715244)
PubChem (23423981)
PubChem (44654663)
PubChem (46937002)
PubChem (56621683)
PubChem (59274407)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (5997)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (1551269)
PubChem (90070115)
PubChem (59450329)
PubChem (59628412)
PubChem (117965027)
PubChem (6432564)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (132837164)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (304)
PubChem (138967089)
PubChem (139566851)
PubChem (89951918)
PubChem (90224410)
PubChem (15939944)
PubChem (91298236)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (638019)
PubChem (101624109)
PubChem (1549081)
PubChem (1553803)
PubChem (171828367)
PubChem (173516975)
PubChem (124225449)
PubChem (124429284)
PubChem (5283629)
PubChem (5284644)
PubChem (5315842)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (6419195)
PubChem (6994560)
PubChem (130459183)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (131992107)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (139568882)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
8H
(R)		(3R)-3-hydroxybutanoic acidnon-polymer104.11Chemie (3HR)
PubChem (441)
PubChem (92135)
PubChem (94318)
9J
(R)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.21Chemie (NAG)
10K
(R)		waterwater18.01Chemie (HOH)
Sequence modifications
A: 3 - 354 (UniProt: P63096)
PDBExternal DatabaseDetails
Asn 47Ser 47conflict
Ala 203Gly 203conflict
Ala 245Glu 245conflict
Ser 326Ala 326conflict
R: 8 - 301 (UniProt: Q8TDS4)
PDBExternal DatabaseDetails
Asn 302-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight144863.6
Non-Polymers*Number of molecules5
Total formula weight1527.1
All*Total formula weight146390.7
*Water molecules are not included.

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PDB entries from 2026-03-25

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