8XZH

Cryo-EM structure of the MM07-bound human APLNR-Gi complex

Summary for 8XZH

• Entry DOI: 10.2210/pdb8xzh/pdb
• EMDB information: 38796
• Descriptor: Apelin receptor, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: aplnr, mm07, class a gpcr, cyclic peptide, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 157143.65

Authors

Wang, W.,Ji, S.,Zhang, Y. (deposition date: 2024-01-21, release date: 2024-03-20, Last modification date: 2024-03-27)

• Primary citation: Wang, W.W.,Ji, S.Y.,Zhang, W.,Zhang, J.,Cai, C.,Hu, R.,Zang, S.K.,Miao, L.,Xu, H.,Chen, L.N.,Yang, Z.,Guo, J.,Qin, J.,Shen, D.D.,Liang, P.,Zhang, Y.,Zhang, Y.; Structure-based design of non-hypertrophic apelin receptor modulator.; Cell, 187:1460-1475.e20, 2024; PubMed: 38428423; DOI: 10.1016/j.cell.2024.02.004

Experimental method

ELECTRON MICROSCOPY (2.6 Å)