8FEG

CryoEM structure of Kappa Opioid Receptor bound to a semi-peptide and Gi1

Summary for 8FEG

• Entry DOI: 10.2210/pdb8feg/pdb
• EMDB information: 29026 42601
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: gpcr, kappa opioid receptor, rosetta, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 150625.13

Authors

Fay, J.F.,Che, T. (deposition date: 2022-12-06, release date: 2023-12-06, Last modification date: 2024-01-17)

• Primary citation: Muratspahic, E.,Deibler, K.,Han, J.,Tomasevic, N.,Jadhav, K.B.,Olive-Marti, A.L.,Hochrainer, N.,Hellinger, R.,Koehbach, J.,Fay, J.F.,Rahman, M.H.,Hegazy, L.,Craven, T.W.,Varga, B.R.,Bhardwaj, G.,Appourchaux, K.,Majumdar, S.,Muttenthaler, M.,Hosseinzadeh, P.,Craik, D.J.,Spetea, M.,Che, T.,Baker, D.,Gruber, C.W.; Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor.; Nat Commun, 14:8064-, 2023; PubMed: 38052802; DOI: 10.1016/0006-2952(73)90196-2

Experimental method

ELECTRON MICROSCOPY (2.54 Å)