7EJX

Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand

Summary for 7EJX

• Entry DOI: 10.2210/pdb7ejx/pdb
• EMDB information: 31164
• Descriptor: Probable G-protein coupled receptor 88, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (8 entities in total)
• Functional Keywords: gpr88, signaling complex, cryo-em, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 157259.50

Authors

Xu, J.,Chen, G.,Liu, Z.,Du, Y. (deposition date: 2021-04-02, release date: 2022-04-13, Last modification date: 2022-10-26)

• Primary citation: Chen, G.,Xu, J.,Inoue, A.,Schmidt, M.F.,Bai, C.,Lu, Q.,Gmeiner, P.,Liu, Z.,Du, Y.; Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex.; Nat Commun, 13:2375-2375, 2022; PubMed: 35501348; DOI: 10.1038/s41467-022-30081-5

Experimental method

ELECTRON MICROSCOPY (2.4 Å)