7EJX
Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | Probable G-protein coupled receptor 88 | polymer | 384 | 40295.9 | 1 | UniProt (Q9GZN0) Pfam (PF00001) In PDB | Homo sapiens (human) | Striatum-specific G-protein coupled receptor |
2 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
3 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 357 | 39286.9 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
5 | S | scFv16 | polymer | 259 | 27784.9 | 1 | Mus musculus (mouse) | ||
6 | R | (1R,2R)-N-[(2S,3S)-2-azanyl-3-methyl-pentyl]-N-[4-(4-propylphenyl)phenyl]-2-pyridin-2-yl-cyclopropane-1-carboxamide | non-polymer | 455.6 | 1 | Chemie (J5F) | |||
7 | R | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) | |||
8 | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
R: 1 - 384 (UniProt: Q9GZN0)
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Ile 190 | Val 190 | variant |
PDB | External Database | Details |
---|---|---|
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 155643.9 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1615.6 | |
All* | Total formula weight | 157259.5 |