7EJX
Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Probable G-protein coupled receptor 88 | polymer | 384 | 40295.9 | 1 | UniProt (Q9GZN0) Pfam (PF00001) | Homo sapiens (human) | Striatum-specific G-protein coupled receptor |
| 2 | B (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 357 | 39286.9 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (S) | scFv16 | polymer | 259 | 27784.9 | 1 | Mus musculus (mouse) | ||
| 6 | F (R) | (1R,2R)-N-[(2S,3S)-2-azanyl-3-methyl-pentyl]-N-[4-(4-propylphenyl)phenyl]-2-pyridin-2-yl-cyclopropane-1-carboxamide | non-polymer | 455.6 | 1 | Chemie (J5F) | |||
| 7 | G, H, I (R) | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) | |||
| 8 | J (R) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
R: 1 - 384 (UniProt: Q9GZN0)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Ile 190 | Val 190 | variant |
| PDB | External Database | Details |
|---|---|---|
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Val -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 155643.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1615.6 | |
| All* | Total formula weight | 157259.5 |
