8IOD

Cryo-EM structure of the PG-901-bound human melanocortin receptor 5 (MC5R)-Gs complex

Summary for 8IOD

• Entry DOI: 10.2210/pdb8iod/pdb
• EMDB information: 35616
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,HiBiT, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: human melanocortin receptor 5, g protein-coupled receptor, pg-901, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 165317.93

Authors

Feng, W.B.,Zhou, Q.T.,Chen, X.Y.,Dai, A.T.,Cai, X.Q.,Liu, X.,Zhao, F.H.,Chen, Y.,Ye, C.Y.,Xu, Y.N.,Cong, Z.T.,Li, H.,Lin, S.,Yang, D.H.,Wang, M.W. (deposition date: 2023-03-10, release date: 2023-09-20, Last modification date: 2023-11-15)

• Primary citation: Feng, W.,Zhou, Q.,Chen, X.,Dai, A.,Cai, X.,Liu, X.,Zhao, F.,Chen, Y.,Ye, C.,Xu, Y.,Cong, Z.,Li, H.,Lin, S.,Yang, D.,Wang, M.W.; Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors.; Cell Discov, 9:81-, 2023; PubMed: 37524700; DOI: 10.1107/S0907444909042073

Experimental method

ELECTRON MICROSCOPY (2.59 Å)