6CRK

Heterotrimeric G-protein in complex with an antibody fragment

Summary for 6CRK

• Entry DOI: 10.2210/pdb6crk/pdb
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: heterotrimeric g-protein antibody fragment, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 114428.43

Authors

Maeda, S.,Dawson, R.,Kobilka, B. (deposition date: 2018-03-19, release date: 2018-10-24, Last modification date: 2023-10-04)

• Primary citation: Maeda, S.,Koehl, A.,Matile, H.,Hu, H.,Hilger, D.,Schertler, G.F.X.,Manglik, A.,Skiniotis, G.,Dawson, R.J.P.,Kobilka, B.K.; Development of an antibody fragment that stabilizes GPCR/G-protein complexes.; Nat Commun, 9:3712-3712, 2018; PubMed: 30213947; DOI: 10.1038/s41467-018-06002-w

Experimental method

X-RAY DIFFRACTION (2 Å)