8JR9

Small molecule agonist (PCO371) bound to human parathyroid hormone receptor type 1 (PTH1R)

Summary for 8JR9

• Entry DOI: 10.2210/pdb8jr9/pdb
• EMDB information: 36593
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: class b, gpcr, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 158833.09

Authors

Zhao, L.,He, Q.,Yuan, Q.,Gu, Y.,He, X.,Shan, H.,Li, J.,Wang, K.,Li, Y.,Hu, W.,Wu, K.,Shen, J.,Xu, H.E. (deposition date: 2023-06-16, release date: 2023-08-02, Last modification date: 2023-10-04)

• Primary citation: Zhao, L.H.,He, Q.,Yuan, Q.,Gu, Y.,He, X.,Shan, H.,Li, J.,Wang, K.,Li, Y.,Hu, W.,Wu, K.,Shen, J.,Xu, H.E.; Conserved class B GPCR activation by a biased intracellular agonist.; Nature, 621:635-641, 2023; PubMed: 37524305; DOI: 10.1038/s41586-023-06467-w

Experimental method

ELECTRON MICROSCOPY (2.57 Å)