8JR9

Small molecule agonist (PCO371) bound to human parathyroid hormone receptor type 1 (PTH1R)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Guanine nucleotide-binding protein G(s) subunit alpha-1	polymer	361	41879.5	1	Pfam (PF00503) UniProt (by SIFTS) (P63096) UniProt (by SIFTS) (P63092) In PDB	Homo sapiens (human)
2	B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	352	38330.8	1	UniProt (P62873) Pfam (PF00400) In PDB	Homo sapiens (human)
3	G	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631) In PDB	Homo sapiens (human)	G gamma-I
4	N	Nanobody 35	polymer	140	15343.0	1		Mus musculus
5	R	Parathyroid hormone/parathyroid hormone-related peptide receptor	polymer	478	54783.0	1	UniProt (Q03431) Pfam (PF02793) Pfam (PF00002) In PDB	Homo sapiens (human)	PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor
6	R	PCO-371	non-polymer		635.7	1	Chemie (KHF)

Sequence modifications

B: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
Leu -1	-	expression tag
Leu 0	-	expression tag
Gln 1	-	expression tag
Gly 341	-	expression tag
Ser 342	-	expression tag
Ser 343	-	expression tag
Gly 344	-	expression tag
Gly 345	-	expression tag
Gly 346	-	expression tag
Gly 347	-	expression tag
Ser 348	-	expression tag

R: 27 - 502 (UniProt: Q03431)

PDB	External Database	Details
Ala 188	Gly 188	conflict
Arg 484	Lys 484	conflict
Glu 503	-	expression tag
Phe 504	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	158197.4
Non-Polymers*	Number of molecules	1
	Total formula weight	635.7
All*	Total formula weight	158833.1

*Water molecules are not included.