7T6S
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![BU of 7t6s by Molmil](/molmil-images/mine/7t6s) | Structure of the human FPR2-Gi complex with compound C43 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Zhuang, Y.W. | Deposit date: | 2021-12-14 | Release date: | 2022-03-30 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Nat Commun, 13, 2022
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7T6T
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![BU of 7t6t by Molmil](/molmil-images/mine/7t6t) | Structure of the human FPR1-Gi complex with fMLFII | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Zhuang, Y.W. | Deposit date: | 2021-12-14 | Release date: | 2022-03-30 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Nat Commun, 13, 2022
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7T6B
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![BU of 7t6b by Molmil](/molmil-images/mine/7t6b) | Structure of S1PR2-heterotrimeric G13 signaling complex | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Li, X, Chen, H. | Deposit date: | 2021-12-13 | Release date: | 2022-04-06 | Last modified: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Structure of S1PR2-heterotrimeric G 13 signaling complex. Sci Adv, 8, 2022
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7SQO
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![BU of 7sqo by Molmil](/molmil-images/mine/7sqo) | Structure of the orexin-2 receptor(OX2R) bound to TAK-925, Gi and scFv16 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | McGrath, A.P, Kang, Y, Flinspach, M. | Deposit date: | 2021-11-05 | Release date: | 2022-05-25 | Last modified: | 2022-07-06 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Molecular mechanism of the wake-promoting agent TAK-925. Nat Commun, 13, 2022
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7SR8
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![BU of 7sr8 by Molmil](/molmil-images/mine/7sr8) | Molecular mechanism of the the wake-promoting agent TAK-925 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Hypocretin receptor type 2, ... | Authors: | Yin, J, Chapman, K, Lian, P, De Brabander, J.K, Rosenbaum, D.M. | Deposit date: | 2021-11-08 | Release date: | 2022-06-08 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Molecular mechanism of the wake-promoting agent TAK-925. Nat Commun, 13, 2022
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7SRS
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![BU of 7srs by Molmil](/molmil-images/mine/7srs) | 5-HT2B receptor bound to LSD in complex with beta-arrestin1 obtained by cryo-electron microscopy (cryoEM) | Descriptor: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 2B, ... | Authors: | Barros-Alvarez, X, Cao, C, Panova, O, Roth, B.L, Skiniotis, G. | Deposit date: | 2021-11-08 | Release date: | 2022-09-21 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron, 110, 2022
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7SRR
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![BU of 7srr by Molmil](/molmil-images/mine/7srr) | 5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by cryo-electron microscopy (cryoEM) | Descriptor: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2B, G protein subunit q (Gi2-mini-Gq chimera), ... | Authors: | Barros-Alvarez, X, Kim, K, Panova, O, Cao, C, Roth, B.L, Skiniotis, G. | Deposit date: | 2021-11-08 | Release date: | 2022-09-21 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron, 110, 2022
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7T2G
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![BU of 7t2g by Molmil](/molmil-images/mine/7t2g) | CryoEM structure of mu-opioid receptor - Gi protein complex bound to mitragynine pseudoindoxyl (MP) | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Seven, A.B, Qu, Q, Robertson, M.J, Wang, H, Kobilka, B.K, Skiniotis, G. | Deposit date: | 2021-12-04 | Release date: | 2022-12-07 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Insights into distinct signaling profiles of the mu OR activated by diverse agonists. Nat.Chem.Biol., 2022
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7T2H
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![BU of 7t2h by Molmil](/molmil-images/mine/7t2h) | CryoEM structure of mu-opioid receptor - Gi protein complex bound to lofentanil (LFT) | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Seven, A.B, Qu, Q, Huang, W, Robertson, M.J, Kobilka, B.K, Skiniotis, G. | Deposit date: | 2021-12-04 | Release date: | 2022-12-07 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Insights into distinct signaling profiles of the mu OR activated by diverse agonists. Nat.Chem.Biol., 2022
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7T90
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![BU of 7t90 by Molmil](/molmil-images/mine/7t90) | Cryo-EM structure of ACh-bound M2R-Go signaling complex in S2 state | Descriptor: | ACETYLCHOLINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | Deposit date: | 2021-12-17 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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7T96
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![BU of 7t96 by Molmil](/molmil-images/mine/7t96) | Cryo-EM structure of S2 state ACh-bound M2R-Go signaling complex with a PAM | Descriptor: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, ACETYLCHOLINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | Deposit date: | 2021-12-18 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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7T8X
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![BU of 7t8x by Molmil](/molmil-images/mine/7t8x) | Cryo-EM structure of ACh-bound M2R-Go signaling complex in S1 state | Descriptor: | ACETYLCHOLINE, Antibody fragment, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | Deposit date: | 2021-12-17 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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7T94
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![BU of 7t94 by Molmil](/molmil-images/mine/7t94) | Cryo-EM structure of S1 state ACh-bound M2R-Go signaling complex with a PAM | Descriptor: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, ACETYLCHOLINE, Antibody fragment, ... | Authors: | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | Deposit date: | 2021-12-17 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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7TUZ
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![BU of 7tuz by Molmil](/molmil-images/mine/7tuz) | Cryo-EM structure of 7alpha,25-dihydroxycholesterol-bound EBI2/GPR183 in complex with Gi protein | Descriptor: | (2S,4aS,4bS,7R,8S,8aS,9R,10aR)-7-[(2R,3R)-7-hydroxy-3,7-dimethyloctan-2-yl]-4a,7,8-trimethyltetradecahydrophenanthrene-2,9-diol, G-protein coupled receptor 183, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Chen, H, Hung, W, Li, X. | Deposit date: | 2022-02-03 | Release date: | 2022-04-13 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response. Structure, 30, 2022
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7U2L
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![BU of 7u2l by Molmil](/molmil-images/mine/7u2l) | C5guano-uOR-Gi-scFv16 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Wang, H, Qu, Q, Skiniotis, G, Kobilka, B. | Deposit date: | 2022-02-24 | Release date: | 2022-05-04 | Last modified: | 2023-02-08 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure-based design of bitopic ligands for the μ-opioid receptor. Nature, 613, 2023
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7U2K
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![BU of 7u2k by Molmil](/molmil-images/mine/7u2k) | C6-guano bound Mu Opioid Receptor-Gi Protein Complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Wang, H, Kobilka, B. | Deposit date: | 2022-02-24 | Release date: | 2022-12-07 | Last modified: | 2023-02-08 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure-based design of bitopic ligands for the μ-opioid receptor. Nature, 613, 2023
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7TMW
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![BU of 7tmw by Molmil](/molmil-images/mine/7tmw) | Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs | Descriptor: | Camelid antibody VHH fragment Nb35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Erlandson, S.C, Rawson, S, Kruse, A.C. | Deposit date: | 2022-01-20 | Release date: | 2023-02-15 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The relaxin receptor RXFP1 signals through a mechanism of autoinhibition. Nat.Chem.Biol., 19, 2023
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7TRQ
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![BU of 7trq by Molmil](/molmil-images/mine/7trq) | Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator VU0467154 | Descriptor: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, 5-amino-3,4-dimethyl-N-{[4-(trifluoromethanesulfonyl)phenyl]methyl}thieno[2,3-c]pyridazine-6-carboxamide, Antibody fragment scFv16, ... | Authors: | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | Deposit date: | 2022-01-30 | Release date: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7TRS
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![BU of 7trs by Molmil](/molmil-images/mine/7trs) | Human M4 muscarinic acetylcholine receptor complex with Gi1 and the endogenous agonist acetylcholine | Descriptor: | ACETYLCHOLINE, Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | Deposit date: | 2022-01-30 | Release date: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7TRP
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![BU of 7trp by Molmil](/molmil-images/mine/7trp) | Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator LY2033298 | Descriptor: | 3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment scFv16, ... | Authors: | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | Deposit date: | 2022-01-30 | Release date: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7TRK
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![BU of 7trk by Molmil](/molmil-images/mine/7trk) | Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo | Descriptor: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Vuckovic, Z, Mobbs, J.I, Belousoff, M.J, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | Deposit date: | 2022-01-29 | Release date: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor Elife, 2023
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7UM5
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![BU of 7um5 by Molmil](/molmil-images/mine/7um5) | CryoEM structure of Go-coupled 5-HT5AR in complex with 5-CT | Descriptor: | 3-(2-azanylethyl)-1H-indole-5-carboxamide, 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhang, S, Fay, J.F, Roth, B.L. | Deposit date: | 2022-04-06 | Release date: | 2022-07-20 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
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7UM4
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![BU of 7um4 by Molmil](/molmil-images/mine/7um4) | Crystal structure of inactive 5-HT5AR in complex with AS2674723 | Descriptor: | 5-hydroxytryptamine receptor 5A, DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, ... | Authors: | Zhang, S, Roth, B.L. | Deposit date: | 2022-04-06 | Release date: | 2022-07-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
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7V3Z
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![BU of 7v3z by Molmil](/molmil-images/mine/7v3z) | Structure of cannabinoid receptor type 1(CB1) | Descriptor: | 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, CHOLESTEROL, FLAVIN MONONUCLEOTIDE, ... | Authors: | Liu, Z.J, Shen, L, Hua, T, Yao, D.Q, Wu, L.J. | Deposit date: | 2021-08-12 | Release date: | 2021-11-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.29 Å) | Cite: | A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1. J.Am.Chem.Soc., 143, 2021
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7UM6
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![BU of 7um6 by Molmil](/molmil-images/mine/7um6) | CryoEM structure of Go-coupled 5-HT5AR in complex with Lisuride | Descriptor: | 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhang, S, Fay, J.F, Roth, B.L. | Deposit date: | 2022-04-06 | Release date: | 2022-07-20 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
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