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7UM6

CryoEM structure of Go-coupled 5-HT5AR in complex with Lisuride

Summary for 7UM6
Entry DOI10.2210/pdb7um6/pdb
EMDB information26598
Descriptor5-hydroxytryptamine receptor 5A, miniGo protein, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
Functional Keywordsgpcr, lisuride, active state, membrane protein, 5-ht5ar, htr5a, go
Biological sourceHomo sapiens (human)
More
Total number of polymer chains5
Total formula weight134208.99
Authors
Zhang, S.,Fay, J.F.,Roth, B.L. (deposition date: 2022-04-06, release date: 2022-07-20, Last modification date: 2022-07-27)
Primary citationZhang, S.,Chen, H.,Zhang, C.,Yang, Y.,Popov, P.,Liu, J.,Krumm, B.E.,Cao, C.,Kim, K.,Xiong, Y.,Katritch, V.,Shoichet, B.K.,Jin, J.,Fay, J.F.,Roth, B.L.
Inactive and active state structures template selective tools for the human 5-HT 5A receptor.
Nat.Struct.Mol.Biol., 29:677-687, 2022
Cited by
PubMed: 35835867
DOI: 10.1038/s41594-022-00796-6
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (2.79 Å)
Structure validation

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