7UM4

Crystal structure of inactive 5-HT5AR in complex with AS2674723

Summary for 7UM4

• Entry DOI: 10.2210/pdb7um4/pdb
• Descriptor: 5-hydroxytryptamine receptor 5A, PGS, TRIETHYLENE GLYCOL, ... (8 entities in total)
• Functional Keywords: gpcr, inactive state, membrane protein, 5-ht5ar, htr5a
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 61523.41

Authors

Zhang, S.,Roth, B.L. (deposition date: 2022-04-06, release date: 2022-07-20, Last modification date: 2023-10-18)

• Primary citation: Zhang, S.,Chen, H.,Zhang, C.,Yang, Y.,Popov, P.,Liu, J.,Krumm, B.E.,Cao, C.,Kim, K.,Xiong, Y.,Katritch, V.,Shoichet, B.K.,Jin, J.,Fay, J.F.,Roth, B.L.; Inactive and active state structures template selective tools for the human 5-HT 5A receptor.; Nat.Struct.Mol.Biol., 29:677-687, 2022; PubMed: 35835867; DOI: 10.1038/s41594-022-00796-6

Experimental method

X-RAY DIFFRACTION (2.8 Å)