7UM4
Crystal structure of inactive 5-HT5AR in complex with AS2674723
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5-hydroxytryptamine receptor 5A | polymer | 336 | 38004.4 | 1 | UniProt (P47898) Pfam (PF00001) | Homo sapiens (human) | 5-HT-5,5-HT-5A,5-HT5A,Serotonin receptor 5A |
| 2 | B (B) | PGS | polymer | 200 | 22251.7 | 1 | Pfam (PF13692) UniProt (by SIFTS) (Q9V2J8) | Homo sapiens (Human) | |
| 3 | C (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 4 | D, F, H (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
| 5 | E (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 6 | G (A) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 7 | I (A) | ~{N}-[azanyl(azanylidene)methylidene]-5-fluoranyl-8-[2,4,6-tris(fluoranyl)phenyl]-3,4-dihydro-1~{H}-isoquinoline-2-carboxamide | non-polymer | 366.3 | 1 | Chemie (NN6) | |||
| 8 | J, K (A, B) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 22 - 357 (UniProt: P47898)
| PDB | External Database | Details |
|---|---|---|
| Asn 86 | Asp 86 | engineered mutation |
| Ala 299 | Ile 299 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 60256.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1267.3 | |
| All* | Total formula weight | 61523.4 |
