7UM4
Crystal structure of inactive 5-HT5AR in complex with AS2674723
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004993 | molecular_function | G protein-coupled serotonin receptor activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007187 | biological_process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0007198 | biological_process | adenylate cyclase-inhibiting serotonin receptor signaling pathway |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0016020 | cellular_component | membrane |
| A | 0021766 | biological_process | hippocampus development |
| A | 0030425 | cellular_component | dendrite |
| A | 0030594 | molecular_function | neurotransmitter receptor activity |
| A | 0032355 | biological_process | response to estradiol |
| A | 0043204 | cellular_component | perikaryon |
| A | 0051378 | molecular_function | serotonin binding |
| A | 0099634 | cellular_component | postsynaptic specialization membrane |
| B | 0016757 | molecular_function | glycosyltransferase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIwNVTAIALDRYWsI |
| Chain | Residue | Details |
| A | ALA127-ILE143 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL41-ALA63 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 111 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| A | THR64-LEU78 | |
| A | ASP138-SER158 | |
| A | TYR220-ARG282 | |
| A | ASN342-HIS357 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL79-VAL99 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 47 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS100-GLN115 | |
| A | GLY182-PRO198 | |
| A | THR304-LYS320 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000250 |
| Chain | Residue | Details |
| A | LEU116-LEU137 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000250 |
| Chain | Residue | Details |
| A | ASN159-TRP181 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000250 |
| Chain | Residue | Details |
| A | SER199-VAL219 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000250 |
| Chain | Residue | Details |
| A | ALA283-LEU303 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000250 |
| Chain | Residue | Details |
| A | SER321-PHE341 |
