7UM4
Crystal structure of inactive 5-HT5AR in complex with AS2674723
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001586 | molecular_function | Gi/o-coupled serotonin receptor activity |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004993 | molecular_function | G protein-coupled serotonin receptor activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007187 | biological_process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0007198 | biological_process | adenylate cyclase-inhibiting serotonin receptor signaling pathway |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0016020 | cellular_component | membrane |
| A | 0021766 | biological_process | hippocampus development |
| A | 0030425 | cellular_component | dendrite |
| A | 0030594 | molecular_function | neurotransmitter receptor activity |
| A | 0032355 | biological_process | response to estradiol |
| A | 0043204 | cellular_component | perikaryon |
| A | 0099589 | molecular_function | serotonin receptor activity |
| A | 0099634 | cellular_component | postsynaptic specialization membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIwNVTAIALDRYWsI |
| Chain | Residue | Details |
| A | ALA127-ILE143 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"35610220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35835867","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X5H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"35610220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35835867","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X5H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"35610220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35835867","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X5H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"35610220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35835867","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X5H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 17 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"35610220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35835867","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X5H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"35610220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35835867","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X5H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"35610220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35835867","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X5H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"35610220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35835867","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X5H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"35610220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35835867","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X5H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"35610220","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35835867","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7UM5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X5H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
