7SQO

Structure of the orexin-2 receptor(OX2R) bound to TAK-925, Gi and scFv16

Summary for 7SQO

Entry DOI	10.2210/pdb7sqo/pdb
EMDB information	25389
Descriptor	Orexin receptor type 2, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total)
Functional Keywords	class a gpcr, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	165739.63
Authors	McGrath, A.P.,Kang, Y.,Flinspach, M. (deposition date: 2021-11-05, release date: 2022-05-25, Last modification date: 2022-07-06)
Primary citation	Yin, J.,Kang, Y.,McGrath, A.P.,Chapman, K.,Sjodt, M.,Kimura, E.,Okabe, A.,Koike, T.,Miyanohana, Y.,Shimizu, Y.,Rallabandi, R.,Lian, P.,Bai, X.,Flinspach, M.,De Brabander, J.K.,Rosenbaum, D.M. Molecular mechanism of the wake-promoting agent TAK-925. Nat Commun, 13:2902-2902, 2022 Cited by PubMed: 35614071 DOI: 10.1038/s41467-022-30601-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.17 Å)

Structure validation