7SQO
Structure of the orexin-2 receptor(OX2R) bound to TAK-925, Gi and scFv16
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Orexin receptor type 2 | polymer | 444 | 50733.3 | 1 | UniProt (O43614) Pfam (PF00001) Pfam (PF03827) | Homo sapiens (human) | Ox-2-R,Ox2-R,Ox2R,Hypocretin receptor type 2 |
| 2 | B (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40459.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 354 | 39151.9 | 1 | UniProt (P62871) Pfam (PF25391) | Bos taurus (cattle) | Transducin beta chain 1 |
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 68 | 7563.8 | 1 | UniProt (P63212) Pfam (PF00631) | Bos taurus (cattle) | G gamma-I |
| 5 | E (E) | scFv-16 | polymer | 247 | 26277.3 | 1 | synthetic construct | ||
| 6 | F, G, H, I (R) | OLEIC ACID | non-polymer | 282.5 | 4 | Chemie (OLA) | |||
| 7 | J (R) | methyl (2R,3S)-3-[(methanesulfonyl)amino]-2-({[(1s,4S)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate | non-polymer | 424.6 | 1 | Chemie (A6F) |
Sequence modifications
R: 1 - 444 (UniProt: O43614)
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62871)
| PDB | External Database | Details |
|---|---|---|
| Val 308 | Ile 308 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asp 206 | Ser 206 | conflict |
| Ser 326 | Ala 326 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | initiating methionine |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| Met -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 164185.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1554.4 | |
| All* | Total formula weight | 165739.6 |
