7TRS

Human M4 muscarinic acetylcholine receptor complex with Gi1 and the endogenous agonist acetylcholine

Summary for 7TRS

• Entry DOI: 10.2210/pdb7trs/pdb
• EMDB information: 26099 26100 26101 26102
• Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Antibody fragment scFv16, ... (6 entities in total)
• Functional Keywords: 7 transmembrane receptor, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 152757.83

Authors

Vuckovic, Z.,Mobbs, J.I.,Belousoff, M.J.,Glukhova, A.,Sexton, P.M.,Danev, R.,Thal, D.M. (deposition date: 2022-01-30, release date: 2023-05-17)

• Primary citation: Thal, D.M.; Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor; Elife, 2023

Experimental method

ELECTRON MICROSCOPY (2.8 Å)