7TUZ

Cryo-EM structure of 7alpha,25-dihydroxycholesterol-bound EBI2/GPR183 in complex with Gi protein

Summary for 7TUZ

• Entry DOI: 10.2210/pdb7tuz/pdb
• EMDB information: 26136
• Descriptor: G-protein coupled receptor 183, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: ebi2, gpr183, oxysterol, gpcr, signaling, immunity, immunocyte migration, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 160296.95

Authors

Chen, H.,Hung, W.,Li, X. (deposition date: 2022-02-03, release date: 2022-04-13, Last modification date: 2022-07-20)

• Primary citation: Chen, H.,Huang, W.,Li, X.; Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response.; Structure, 30:1016-, 2022; PubMed: 35537452; DOI: 10.1016/j.str.2022.04.006

Experimental method

ELECTRON MICROSCOPY (3.12 Å)