7T90
Cryo-EM structure of ACh-bound M2R-Go signaling complex in S2 state
Summary for 7T90
Entry DOI | 10.2210/pdb7t90/pdb |
Related | 7T8X |
EMDB information | 25749 |
Descriptor | Muscarinic acetylcholine receptor M2, Guanine nucleotide-binding protein G(o) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total) |
Functional Keywords | gpcr, signaling complex, muscarinic receptor, acetylcholine, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 152910.45 |
Authors | Xu, J.,Wang, Q.,Du, Y.,Kobilka, B.K. (deposition date: 2021-12-17, release date: 2023-01-25, Last modification date: 2024-02-07) |
Primary citation | Xu, J.,Wang, Q.,Hubner, H.,Hu, Y.,Niu, X.,Wang, H.,Maeda, S.,Inoue, A.,Tao, Y.,Gmeiner, P.,Du, Y.,Jin, C.,Kobilka, B.K. Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14:376-376, 2023 Cited by PubMed: 36690613DOI: 10.1038/s41467-022-35726-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.32 Å) |
Structure validation
Download full validation report