7UM5
CryoEM structure of Go-coupled 5-HT5AR in complex with 5-CT
Summary for 7UM5
Entry DOI | 10.2210/pdb7um5/pdb |
EMDB information | 26597 |
Descriptor | 5-hydroxytryptamine receptor 5A, miniGo protein, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total) |
Functional Keywords | gpcr, 5-ct, active state, membrane protein, 5-ht5ar, htr5a, go |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 134073.78 |
Authors | Zhang, S.,Fay, J.F.,Roth, B.L. (deposition date: 2022-04-06, release date: 2022-07-20, Last modification date: 2022-07-27) |
Primary citation | Zhang, S.,Chen, H.,Zhang, C.,Yang, Y.,Popov, P.,Liu, J.,Krumm, B.E.,Cao, C.,Kim, K.,Xiong, Y.,Katritch, V.,Shoichet, B.K.,Jin, J.,Fay, J.F.,Roth, B.L. Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29:677-687, 2022 Cited by PubMed: 35835867DOI: 10.1038/s41594-022-00796-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.73 Å) |
Structure validation
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