7UM5
CryoEM structure of Go-coupled 5-HT5AR in complex with 5-CT
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5-hydroxytryptamine receptor 5A | polymer | 326 | 36884.2 | 1 | UniProt (P47898) Pfam (PF00001) | Homo sapiens (human) | 5-HT-5,5-HT-5A,5-HT5A,Serotonin receptor 5A |
| 2 | B (B) | miniGo protein | polymer | 225 | 25159.8 | 1 | Homo sapiens (Human) | ||
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (E) | Single-chain variable fragment scFv16 | polymer | 251 | 26679.7 | 1 | Mus musculus (Mouse) | ||
| 6 | F (A) | 3-(2-azanylethyl)-1H-indole-5-carboxamide | non-polymer | 203.2 | 1 | Chemie (8K3) | |||
| 7 | G (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 32 - 357 (UniProt: P47898)
| PDB | External Database | Details |
|---|---|---|
| Pro 146 | His 146 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 133870.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 203.2 | |
| All* | Total formula weight | 134073.8 |
