7TMW
Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs
Summary for 7TMW
Entry DOI | 10.2210/pdb7tmw/pdb |
EMDB information | 26003 |
Descriptor | Relaxin receptor 1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short fusion, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (4 entities in total) |
Functional Keywords | gpcr, complex, signaling, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 177282.42 |
Authors | Erlandson, S.C.,Rawson, S.,Kruse, A.C. (deposition date: 2022-01-20, release date: 2023-02-15, Last modification date: 2023-08-09) |
Primary citation | Erlandson, S.C.,Rawson, S.,Osei-Owusu, J.,Brock, K.P.,Liu, X.,Paulo, J.A.,Mintseris, J.,Gygi, S.P.,Marks, D.S.,Cong, X.,Kruse, A.C. The relaxin receptor RXFP1 signals through a mechanism of autoinhibition. Nat.Chem.Biol., 19:1013-1021, 2023 Cited by PubMed: 37081311DOI: 10.1038/s41589-023-01321-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
Download full validation report